Evidence map›Paper›PMID 32173305›Full record

ArticleJournal of geriatric oncology2020

Patient-reported cognitive complaints in older adults with gastrointestinal malignancies at diagnosis- Results from the Cancer & Aging Resilience Evaluation (CARE) study.

Nabiel Mir, Paul MacLennan, Mustafa Al-Obaidi, Donna Murdaugh, Kelly M Kenzik, Andrew McDonald, Noha Sharafeldin, Crystal Young-Smith, Ravi Paluri, Olumide Gbolahan and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Incidence and predictors of immune checkpoint inhibitor treatment-related cognitive impairment in a racial and ethnic diverse population.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  12. Patient-Reported Outcomes Measurement Information System in patients with gastrointestinal cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  15. Pain among older adults with gastrointestinal malignancies- results from the cancer and aging resilience evaluation (CARE) Registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nabiel MirDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: nabielmir@uabmc.edu.
Paul MacLennanDepartment of Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL, USA.
Mustafa Al-ObaidiInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Donna MurdaughInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Kelly M KenzikInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Andrew McDonaldInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Noha SharafeldinInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Crystal Young-SmithDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Institute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Ravi PaluriDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Olumide GbolahanDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Lakshmin NandagopalDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Smita BhatiaInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Grant R WilliamsDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Institute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAMKL2TR003097 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$5.2M
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M StudyK08CA234225 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, GRANT R · 2018 to 2022
$1.0M
NCATS NIH HHS KL2 TR003097NCI NIH HHS K08 CA234225
6 · The paper itself

Abstract

objectivesPatient-reported cognitive complaint (CI) is poorly described in older adults with cancer. The purpose of this study was to quantify the prevalence and examine the associations of patient-reported CI in older adults with gastrointestinal (GI) malignancies at diagnosis. MATERIALS AND

methodsUsing participants ≥60 years with GI malignancies from the Cancer & Aging Resilience Evaluation (CARE) Registry that underwent a Geriatric Assessment (GA), we examined CI using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Short Form 4a Cognitive Function. Cognition scores were dichotomized into normal (scores of 15-20) and impaired (4-14), and bivariate and multivariate analyses were used to examine associations.

resultsA total of 264 participants with GI malignancy were included, mean age of 70.0 ± 7.1, 55.7% male, pancreatic cancer was the most common cancer (24.2%) and majority were stage III/IV (68.2%). 29.3% of participants endorsed CI. CI was not associated with demographic and clinical domains, but was associated with many GA impairments including instrumental Activities of Daily Living (iADL) impairment (adjusted odds ratio [aOR] 6.0, 95% confidence interval 3.0-11.8), falls (aOR 2.7, 1.4-5.4), anxiety (aOR 10.3, 5.2-20.4), and depression (aOR 10.2, 5.2-20.4). CI was also associated with reduced global mental (aOR 18.7, 8.1-42.2) and physical (aOR 4.7, 2.4-8.9) quality of life, and prior hospitalizations (aOR 2.4, 1.2-4.8).

conclusionWe found a high prevalence of patient-reported CI in older adults with GI malignancies that was associated with increased GA impairments, reduced health-related quality of life, and increased healthcare utilization.

Indexed as

Activities of Daily LivingCognitionGastrointestinal NeoplasmsPatient Reported Outcome MeasuresAgedAgingFemaleGeriatric AssessmentHumansMaleQuality of LifeCancer-related cognitive impairmentGastrointestinal malignanciesGeriatric assessmentGeriatric oncologyPatient-reported outcomes

Identifiers

PMID32173305
PMCPMC7332372
OpenAlexW3011340979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.