Observational studyOphthalmology2020
Longitudinal Macular Structure-Function Relationships in Glaucoma.
Observational study in Ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 60 citations in OpenAlex.
- Multicenter OCT-Based Visual Field Representations via Segmentation-Free 3D CNNs: Forecasting, Longitudinal Variability, and Progression Detection.Translational vision science & technology · 2026Article
- The retinal nerve fibre layer thickness slope: a localised biomarker of the structure-function relationship in early glaucoma.The British journal of ophthalmology · 2026Article
- Deep Learning Prediction of Personalized Peripapillary Retinal Nerve Fiber Layer Thickness Norms from Fundus Images in Glaucoma.medRxiv : the preprint server for health sciences · 2026Article
- Point-to-Point Macular Structure-Function Relationships in Healthy and Glaucomatous Eyes Using OCT and Microperimetry.Journal of clinical medicine · 2026Article
- An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data.American journal of ophthalmology · 2026Article
- A Bayesian Hierarchical Longitudinal Model for Estimation of Central Visual Field Rates of Change in Glaucoma.Translational vision science & technology · 2025Article
- MEDTEG (Minimum Entropy Dynamic Test Grids): A Novel Algorithm for Adding New Test Locations to a Perimetric Test Grid.Translational vision science & technology · 2025Article
- Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma.Investigative ophthalmology & visual science · 2024Article
- A SPATIALLY VARYING HIERARCHICAL RANDOM EFFECTS MODEL FOR LONGITUDINAL MACULAR STRUCTURAL DATA IN GLAUCOMA PATIENTS.The annals of applied statistics · 2024Article
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves' Orbitopathy.Diagnostics (Basel, Switzerland) · 2024Article
- Assessment of the relationship between structural and functional tests in patients with idiopathic intracranial hypertension.International ophthalmology · 2024Observational
- Comparison of the Circumpapillary Structure-Function and Vasculature-Function Relationships at Different Glaucoma Stages Using Longitudinal Data.Investigative ophthalmology & visual science · 2024Article
- A Bayesian Hierarchical Spatial Longitudinal Model Improves Estimation of Local Macular Rates of Change in Glaucomatous Eyes.Translational vision science & technology · 2024Article
- Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.American journal of ophthalmology · 2024Article
- Cost-efficient and glaucoma-specifical model by exploiting normal OCT images with knowledge transfer learning.Biomedical optics express · 2023Article
- Prediction of Central Visual Field Measures From Macular OCT Volume Scans With Deep Learning.Translational vision science & technology · 2023Article
- Comparing Rates of Change in Moderate to Advanced Glaucoma: Retinal Nerve Fiber Layer Versus Bruch Membrane Opening-Minimum Rim Width.American journal of ophthalmology · 2023Article
- Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity.Investigative ophthalmology & visual science · 2023Article
- Importance of Pattern Standard Deviation of Humphrey 10-2 Visual Field to Evaluate Central Visual Function in Patients with Early-Stage Glaucoma.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
purposeTo investigate the relationship between longitudinal changes in macular thickness measurements from OCT and changes in central visual field (VF) in patients with glaucoma with central or advanced damage at baseline.
designLongitudinal cohort study.
participantsA total of 116 eyes with ≥3 years of follow-up and ≥5 macular OCT images and central 10° VF tests were selected.
methodsOCT superpixels and VF locations were matched correcting for retinal ganglion cell (RGC) displacement. Superpixel thickness and VF total deviation (TD) values, in both logarithmic and linear scales, were averaged within 3 eccentricities (3.4°, 5.6°, and 6.8°) and superior and inferior hemiretinas and hemifields. We estimated pointwise TD rates of change and rates of change at superpixels for full macular thickness (FMT), ganglion cell complex (GCC), ganglion cell inner plexiform layer (GCIPL), and ganglion cell layer (GCL). Correlation of structure-function (SF) rates of change was investigated with parametric tests. We compared the proportion of worsening and positive slopes for superpixels and VF test locations (negative vs. positive rates of change with P < 0.05) throughout the follow-up period. Permutation analyses were used to control specificity.
main outcome measuresMagnitude of correlation between structural and functional rates of change and proportion of worsening and positive slopes as a function of follow-up time.
resultsThe median (interquartile range) follow-up and number of exams were 4.2 (3.7-4.6) years and 8 (7-9), respectively. The highest correlation of change rates was observed at 3.4° and 5.6° eccentricities (r = 0.24, 0.41, 0.40, and 0.40 for FMT, GCC, GCIPL, and GCL for 3.4° eccentricity and r = 0.28, 0.32, 0.31, and 0.32 for FMT, GCC, GCIPL, and GCL for 5.6° eccentricity, respectively). Although GCC measures demonstrated the highest overall longitudinal SF correlations, the differences were not statistically significant. Significant structural worsening was more frequently detected than functional deterioration at 3- and 5-year time points (P < 0.025). Permutation analyses also confirmed this finding.
conclusionsCorrelations between central structural and functional rates of change were weak to fair in this cohort. Structural changes were detected more frequently than functional changes. Measurements of both structure and function are required for optimal detection of central progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.