Evidence map›Paper›PMID 32172813›Full record

ReviewCritical care clinics2020

Red Blood Cell Dysfunction in Critical Illness.

Stephen Rogers, Allan Doctor

Open access · bronzeAbstract readReview
In one paragraph

Review in Critical care clinics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Two-centers machine learning analysis for predicting acid-fast bacilli results in tuberculosis sputum tests.Journal of clinical tuberculosis and other mycobacterial diseases · 2025
    Article
  4. Article
  5. Review
  6. The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Sepsis: Evidence-based pathogenesis and treatment.World journal of critical care medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephen RogersDepartment of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, HSF III, 8th Floor, 670 West Baltimore Street, Baltimore, MD 21204, USA.
Allan DoctorDepartment of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, HSF III, 8th Floor, 670 West Baltimore Street, Baltimore, MD 21204, USA. Electronic address: adoctor@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Treating Brain Swelling in Pediatric Cerebral MalariaU01AI126610 · NIAID · MICHIGAN STATE UNIVERSITY · PI TAYLOR, TERRIE ELLEN · 2017 to 2023
$9.1M
SEPSIS-INDUCED RED CELL DYSFUNCTION (SIRD)R01GM113838 · NIGMS · WASHINGTON UNIVERSITY · PI DOCTOR, ALLAN, MCMAHON, TIMOTHY J · 2015 to 2019
$4.0M
ErythroMer: Nanoscale Bio-Synthetic Red Cell SubstituteR42HL135965 · NHLBI · KALOCYTE, INC. · PI MITTAL, NIVESH KUMAR · 2017 to 2019
$2.0M
NHLBI NIH HHS R42 HL135965NIAID NIH HHS U01 AI126610NIGMS NIH HHS R01 GM113838
6 · The paper itself

Abstract

Oxygen (O2) delivery, which is fundamental to supporting patients with critical illness, is a function of blood O2 content and flow. This article reviews red blood cell (RBC) physiology and dysfunction relevant to disordered O2 delivery in the critically ill. Flow is the focus of O2 delivery regulation: O2 content is relatively fixed, whereas flow fluctuates greatly. Thus, blood flow volume and distribution vary to maintain coupling between O2 delivery and demand. This article reviews conventional RBC physiology influencing O2 delivery and introduces a paradigm for O2 delivery homeostasis based on coordinated gas transport and vascular signaling by RBCs.

Indexed as

Critical IllnessAdenosine TriphosphateErythrocyte DeformabilityErythrocytesHemorheologyHomeostasisHumansMicrocirculationNitric OxideAdenosine TriphosphateNitric OxideBlood flowErythrocyteO(2) deliveryRed blood cellVasoregulation

Identifiers

PMID32172813
PMCPMC7183574
OpenAlexW3005746254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.