SynthesisJournal of the American Heart Association2020
Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Effect of coronary artery bypass grafting on quality of life: a meta-analysis of randomized trials.European heart journal. Quality of care & clinical outcomes · 2022Pooled it
- Health and Well-Being in Surviving Congenital Heart Disease Patients: An Umbrella Review With Synthesis of Best Evidence.Frontiers in cardiovascular medicine · 2022Pooled it
- Health-related quality of life in adults with tetralogy of Fallot repair: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Exercise Capacity, Endothelial Function, Muscle Mass, and Strength in Pediatric Patients With Fontan Circulation.CJC pediatric and congenital heart disease · 2026Article
- Neonatal brain structure, cognitively stimulating parenting and behavioural outcomes in preschool children with congenital heart disease and controls.Scientific reports · 2026Article
- Update on Education for Families and Patients With Pediatric Heart Disease: A Focus on Technological Advancements, Procedures, and Transitions of Care: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2026Review
- Psychological Aspects and Mental Health Risks in Children and Adolescents with Congenital Heart Defects-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- Palliative Care Education in Pediatric Cardiology Fellowships: A Survey of Program Directors.Pediatric cardiology · 2026Article
- Health-Related Quality of Life in Children with Hypoplastic Left Heart Syndrome: Changes over Time and Associations with Neurodevelopmental and Clinical Factors.The Journal of pediatrics · 2026Article
- Comparative Analysis of Respiratory and Functional Outcomes in Children Post-Fontan Procedure Versus Healthy Peers.Pediatric cardiology · 2025Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Isomerism of the right atrial appendages with bilateral eparterial bronchi: clinical challenges and surgical management guided by 3D cardiac computed tomography.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Review
- Differences in Exercise Performance in Fontan Patients with Extracardiac Conduit and Lateral Tunnel: A FORCE Fontan Registry Study.Journal of clinical medicine · 2025Article
- Correlation between Olink and SomaScan proteomics platforms in adults with a Fontan circulation.International journal of cardiology. Congenital heart disease · 2025Article
- Quality of Life in the Danish Fontan Population is Unchanged Over the Past Decade-A Nationwide Longitudinal Study.Pediatric cardiology · 2025Article
- Promoting emotional & behavioral health for pediatric patients with Fontan circulation: integrating psychology into a dedicated multidisciplinary clinic.Frontiers in cardiovascular medicine · 2025Article
- Quality of Life and Well-Being in Adults With Fontan Physiology: Findings From the Australian and New Zealand Fontan Registry Quality of Life Study.Journal of the American Heart Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background People with a Fontan circulation experience a range of physical, psychosocial and neurodevelopmental challenges alongside, or caused by, their cardiac condition, with significant consequences for health-related quality of life (HRQOL). We meta-analyzed HRQOL outcomes reported by people with a Fontan circulation or their proxies and evaluated predictors of poorer HRQOL. Methods and Results Six electronic databases were searched for peer-reviewed, English-language articles published before March 2019. Standardized mean differences (SMD) were calculated using fixed and random-effects models. Fifty articles reporting on 29 unique studies capturing HRQOL outcomes for 2793 people with a Fontan circulation and 1437 parent-proxies were analyzed. HRQOL was lower in individuals with a Fontan circulation compared with healthy referents or normative samples (SMD, -0.92; 95% CI, -1.36 to -0.48;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.