Evidence map›Paper›PMID 32172476›Full record

ArticleEJNMMI research2020

PET quantification of brain O-GlcNAcase with [

Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L Morse, Mohammad B Haskali, Lester Manly, Sergey Shcherbinin, J Craig Ruble, Nancy Kant, Emily C Collins and 5 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase.American journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Disentangling tau: One protein, many therapeutic approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  7. Review
  8. Development of a Novel [ACS chemical neuroscience · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. The Use, Standardization, and Interpretation of Brain Imaging Data in Clinical Trials of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Jae-Hoon LeeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA. jae-hoon.lee@nih.gov.ORCID http://orcid.org/0000-0002-9898-9886
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Soumen PaulMolecular Imaging Core, University of Virginia, Charlottesville, VA, USA.
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Mohammad B HaskaliThe Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, Melbourne, Australia.
Lester ManlyMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Sergey ShcherbininEli Lilly and Company, Indianapolis, IN, USA.
J Craig RubleEli Lilly and Company, Indianapolis, IN, USA.
Nancy KantEli Lilly and Company, Indianapolis, IN, USA.
Emily C CollinsEli Lilly and Company, Indianapolis, IN, USA.
Hugh N NuthallEli Lilly and Company, Indianapolis, IN, USA.
Paolo Zanotti-FregonaraHouston Methodist Research Institute, Houston, TX, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
National Institutes of Health · USEli Lilly (United States) · USHouston Methodist · USPeter MacCallum Cancer Centre · AUUniversity of Virginia · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
NIMH NIH HHS ZIAMH002793 and ZIAMH002852
6 · The paper itself

Abstract

backgroundPrevious studies found that [

methodsKinetic evaluation of [

resultsBrain uptake was generally high and could be quantified as V

conclusions[

Indexed as

NeuroimagingO-GlcNAcasePositron emission tomographyTauopathyTest-retest reliability

Identifiers

PMID32172476
PMCPMC7072082
OpenAlexW3011383635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.