Observational studyRheumatology international2020
Peripheral neuropathy and health-related quality of life in patients with primary Sjögren's syndrome: a preliminary report.
Observational study in Rheumatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology (Oxford, England) · 2025Guideline
- NETs mediate neuropathic pain in PSS-PN by participating in inflammatory injury to the vasa nervorum.Clinical rheumatology · 2026Article
- Low albumin-to-globulin ratio is associated with interstitial lung disease in primary Sjögren's syndrome: a single-center retrospective cohort study with propensity score matching.Rheumatology international · 2026Article
- Health-Related Quality of Life in Primary Sjögren's Syndrome: Oral Manifestations and Patient-Reported Outcomes.Dentistry journal · 2026Article
- Prevalence of Small A-Delta Fiber Neuropathy in Sjögren's Disease: Findings from a Cohort Study.International journal of molecular sciences · 2025Article
- From Autoimmune Sialadenitis to Central Pain: Hypothesizing Shared Pathogenesis for Fibromyalgia and Primary Sjogren's Disease and Identifying Essential Screening Strategies.International journal of molecular sciences · 2025Article
- Overall Health Status of Patients with Mild-to-Moderate Cubital Tunnel Syndrome: A Case-Control Study.Healthcare (Basel, Switzerland) · 2025Article
- Underestimated pyridoxine consumption and neurotoxicity: a novel manifestation with rheumatologic relevance - a case-based review.Rheumatology international · 2025Review
- Sjögren's syndrome increased risk of attempted suicide.Scientific reports · 2025Article
- Distinct characteristics of carpal tunnel syndrome among Sjögren's disease patients and their clinical implications.Reumatologia · 2025Article
- Characteristics of primary Sjögren's syndrome-associated peripheral nervous system lesions.Journal of neurology · 2023Article
- Diagnostic markers and potential therapeutic agents for Sjögren's syndrome screened through multiple machine learning and molecular docking.Clinical and experimental immunology · 2023Article
- Peripheral nervous system involvement in Sjogren's syndrome and its impact on quality of life.Clinical and experimental medicine · 2023Observational
- Analysis of clinical features and risk factors of peripheral neuropathy in patients with primary Sjögren's syndrome.European journal of medical research · 2023Article
- High-resolution ultrasound of peripheral neuropathies in rheumatological patients: An overview of clinical applications and imaging findings.Frontiers in medicine · 2022Review
- Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected.Diagnostics (Basel, Switzerland) · 2021Review
- National Sjögren's Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life.The Journal of rheumatology · 2021Article
- Peripheral Nervous System Involvement in Sjögren's Syndrome: Analysis of a Cohort From the Italian Research Group on Sjögren's Syndrome.Frontiers in immunology · 2021Article
- Clinical and serological characteristics of peripheral neuropathy in patients with primary Sjögren's syndrome.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sjögren's syndrome (SS) is a chronic autoimmune disease with a wide spectrum of possible organ involvement. Peripheral (PNS) and central nervous system (CNS)-related symptoms may occur in the course of the disease. The aim of this study was to compare the health-related quality of life (HR-QOL) in SS patients with and without peripheral neuropathy. The study involved 50 patients with primary Sjögren's syndrome (pSS). All patients underwent neurological clinical examination followed by nerve conduction studies (NCS) and rheumatological examination. Thirty-six-item Short Form Health Survey (SF-36) was used for evaluating HR-QOL. To assess pSS activity, the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) and EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) were used. For the assessment of clinical disability due to peripheral neuropathy, the Overall Disability Sum Score scale (ODSS) was used. Additional evaluation of pain was performed with the use of the Visual Analogue Scale (VAS) and a semistructured interview. Twenty-three (46%) patients were diagnosed with peripheral neuropathy. The most common PNS manifestation was sensorimotor neuropathy (47%). Neurological symptoms preceded the diagnosis of pSS in eight patients. The following domains of the SF-36 form were significantly lower scored by patients with peripheral nervous system involvement: role-physical [0 (0-100) vs. 75 (0-100)], role-emotional [67 (0-100) vs. 100 (0-100)], vitality [40 (10-70) vs. 50 (20-75)], bodily pain [45 (10-75) vs. 55 (0-100)], and general health [20 (5-50) vs. 30 (0-50)] (p ≤ 0.05). Our study showed that peripheral neuropathy was a common organ-specific complication in SS patients. In pSS patients, coexisting neurological involvement with symptoms such as pain and physical disability may be responsible for diminished HR-QOL.
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