ArticleInternational journal of hematology2020
Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors.
Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Supportive Care of Hematopoietic Stem Cell Donors.Clinical hematology international · 2024Article
- A survey on preoperative autologous blood donation policy in bone marrow stem cell donors in Italy.Blood transfusion = Trasfusione del sangue · 2023Article
- Should We Stop Collecting the Preoperative Autologous Blood before Bone Marrow Harvest?Journal of clinical medicine · 2021Article
- Patient Blood Management in pediatric and adolescent bone marrow donors: results from an Italian survey.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the Japan Marrow Donor Program (JMDP), autologous blood is collected from most unrelated bone marrow (BM) donors. We retrospectively evaluated 5772 donors who underwent BM harvest between 2010 and 2015 through the JMDP. Autologous blood was collected in 96.8% of the donors; the wastage rate was 0.6%. Allogeneic blood transfusion was not required. The mean hemoglobin (Hb) levels were 12.1 g/dL after the BM harvest (mean 891 mL) together with autologous blood transfusion (mean 596 mL). Propensity-score matching was used to adjust the backgrounds. Among donors with harvested BM of 100-400 mL, autologous blood transfusion had no impact on Hb levels or complications after BM harvest. Among donors with harvested BM of > 400 mL, more autologous blood transfusion followed by a bleeding volume of ≤ 100 mL did not confer clinical benefit to donors compared with less autologous blood transfusion followed by a bleeding volume of > 300 mL. The findings of the present study suggest that autologous blood transfusion to BM donors is excessive in terms of Hb changes and post-harvest outcomes.
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