Evidence map›Paper›PMID 32172446›Full record

ArticleInternational journal of hematology2020

Health-related quality of life in peripheral blood stem cell donors and bone marrow donors: a prospective study in Japan.

Ayumi Fujimoto, Ritsuro Suzuki, Katsumi Orihara, Minako Iida, Takuya Yamashita, Koji Nagafuji, Heiwa Kanamori, Yoshihisa Kodera, Koichi Miyamura, Shinichiro Okamoto and 1 more

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In one paragraph

Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Ayumi FujimotoDepartment of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.
Ritsuro SuzukiDepartment of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.
Katsumi OriharaJapan Marrow Donor Program, Tokyo, Japan.
Minako IidaDepartment of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan.
Takuya YamashitaDepartment of Hematology, St. Luke's International Hospital, Tokyo, Japan.
Koji NagafujiDivision of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
Heiwa KanamoriDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Yoshihisa KoderaDepartment of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan.
Koichi MiyamuraDepartment of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
Shinichiro OkamotoDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Masayuki HinoDepartment of Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan. hinom@med.osaka-cu.ac.jp.
Aichi Medical University · JPShimane University Hospital · JPKanagawa Prefectural Hospital Organization · JPKeio University · JPKurume University · JPOsaka City University · JPSt. Luke's International Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding of the impact of stem cell donation on donors' health-related quality of life (HRQOL) remains limited. A prospective observational study of eligible unrelated donors enrolled in the Japan Marrow Donor Program was conducted to compare HRQOL and adverse events (AEs) between peripheral blood stem cell (PBSC) and bone marrow (BM) donors. In total, 107 PBSC donors and 108 BM donors were enrolled. HRQOL scores for physical status were significantly lower in BM donors 1 week post-harvest (P < 0.001), but there were no significant differences between the two groups at baseline or 3 months post-harvest. PBSC donors were more likely to experience AEs before harvest (P < 0.001). However, at harvest, moderate-to-severe AEs were more common in BM donors (P = 0.001). After harvest, all grades of AEs were significantly higher in BM donors (P < 0.001). Among BM donors, a lower total physical score at baseline [odds ratio (OR) 1.21], female sex [OR 2.71], and young donors (OR 3.08) were risk factors for moderate-to-severe AEs at harvest, while among PBSC donors, only female sex (OR 4.86) was a risk factor. Our findings show better HRQOL during PBSC donation. These data help support decision-making by potential donors.

Indexed as

Bone MarrowHealthPeripheral Blood Stem CellsQuality of LifeStem CellsTissue DonorsAge FactorsFemaleHumansJapanMaleProspective StudiesRisk FactorsSex FactorsTissue and Organ HarvestingAdverse eventsHealth-related quality of lifeRisk factorsStem cell donors

Identifiers

PMID32172446
OpenAlexW3012443104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.