Evidence map›Paper›PMID 32172444›Full record

ReviewCurrent osteoporosis reports2020

Pharmacologic Treatments to Preserve Bone and Muscle Mass in Osteosarcopenia.

Gordon L Klein

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Musculoskeletal Issues in Pediatric Burn Patients.Seminars in plastic surgery · 2024
    Review
  3. Review
  4. Article
  5. Osteosarcopenia: A Narrative Review on Clinical Studies.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gordon L KleinDepartment of Orthopaedic Surgery and Rehabilitaton, University of Texas Medical Branch, Galveston, TX, 77555-0165, USA. gordonklein@ymail.com.ORCID 0000-0002-3011-4186
The University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWe aim to recast the diagnosis of osteosarcopenia in light of its pathophysiology rather than of the age at which it is diagnosed. We will consider why we think the diagnosis of osteosarcopenia is missed in those who are not elderly and why pharmacologic treatment based on pathophysiology rather than age may provide a more comprehensive treatment for patients with the condition. RECENT

findingsWe will present recent findings on the pathogenesis of osteosarcopenia from two distinct groups of patients which will highlight why pathophysiology is of paramount importance in designing treatment. We will show that in patients with cancer and burns, muscle catabolic factors are released from bone on resorption, exert a paracrine effect on muscle to cause catabolism, and can be prevented with the use of anti-resorptive drugs. New uses for anti-resorptives may result from these findings.

Indexed as

Adipose TissueBone Density Conservation AgentsBone Diseases, MetabolicBone ResorptionBurnsHumansNeoplasmsParacrine CommunicationSarcopeniaBone Density Conservation AgentsBisphosphonatesBoneMuscleMuscle catabolic factorsOsteosarcopenia

Identifiers

PMID32172444
OpenAlexW3011514679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.