ArticleIntensive care medicine experimental2020
New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma.
Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes.Journal of leukocyte biology · 2021Trial
- Hallmarks of the multidimensional immune response to trauma in humans.Nature immunology · 2026Review
- Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Association of CD16Journal of inflammation research · 2026Article
- Increased Bacterial Load per Neutrophil Reduces Intracellular Killing Capacity.Journal of innate immunity · 2026Article
- Dysregulation of neutrophil in sepsis: recent insights and advances.Cell communication and signaling : CCS · 2025Review
- Neutrophil phenotypes quantify tissue damage caused by major surgery.Frontiers in surgery · 2025Article
- Limited impact of traumatic brain injury on the post-traumatic inflammatory cellular response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Visualization of the inflammatory response to injury by neutrophil phenotype categories : Neutrophil phenotypes after trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Multiparametric Profiling of Neutrophil Function via a High-Throughput Flow Cytometry-Based Assay.Cells · 2023Article
- Association Between Neutrophil Density and Survival in Trauma Patients Admitted to the Intensive Care Unit; a Retrospective Cohort Study.Archives of academic emergency medicine · 2023Article
- Simultaneous Measurement of Changes in Neutrophil Granulocyte Membrane Potential, Intracellular pH, and Cell Size by Multiparametric Flow Cytometry.Biomedicines · 2021Article
- Neutrophil kinetics and function after major trauma: A systematic review.World journal of critical care medicine · 2021Article
- Effect of Anti-Inflammatory and Antimicrobial Cosupplementations on Sepsis Prevention in Critically Ill Trauma Patients at High Risk for Sepsis.Frontiers in pharmacology · 2021Article
- Alterations of Phagocytic Activity and Capacity in Granulocytes and Monocytes Depend on the Pathogen Strain in Porcine Polytrauma.Frontiers in medicine · 2021Article
- Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation.Frontiers in immunologyArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these infections by phagocytosis and killing of pathogens. Analysis of neutrophil function used to be laborious and was therefore not applicable in routine diagnostics. Hence, we developed a quick and point-of-care method to assess a critical part of neutrophil function, neutrophil phagosomal acidification. The aim of this study was to investigate whether this method was able to analyze neutrophil functionality in severely injured patients and whether a relation with the development of infectious complications was present.
resultsFifteen severely injured patients (median ISS of 33) were included, of whom 6 developed an infection between day 4 and day 9 after trauma. The injury severity score did not significantly differ between patients who developed an infection and patients who did not (p = 0.529). Patients who developed an infection showed increased acidification immediately after trauma (p = 0.006) and after 3 days (p = 0.026) and a decrease in the days thereafter to levels in the lower normal range. In contrast, patients who did not develop infectious complications showed high-normal acidification within the first days and increased tasset to identify patients at risk for infections after trauma and to monitor the inflammatory state of these trauma patients.
conclusionNeutrophil function can be measured in the ICU setting by rapid point-of-care analysis of phagosomal acidification. This analysis differed between trauma patients who developed infectious complications and trauma patients who did not. Therefore, this assay might prove a valuable asset to identify patients at risk for infections after trauma and to monitor the inflammatory state of these trauma patients.
trial registrationCentral Committee on Research Involving Human Subjects, NL43279.041.13. Registered 14 February 2014. https://www.toetsingonline.nl/to/ccmo_search.nsf/Searchform?OpenForm.
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