Evidence map›Paper›PMID 32172351›Full record

ReviewDrug delivery and translational research2020

Immune cell engineering: opportunities in lung cancer therapeutics.

Arpit Bhargava, Dinesh Kumar Mishra, Rajnarayan Tiwari, Nirmal Kumar Lohiya, Irina Yu Goryacheva, Pradyumna Kumar Mishra

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arpit BhargavaDepartment of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India.
Dinesh Kumar MishraIndore Institute of Pharmacy, Indore, India.
Rajnarayan TiwariDepartment of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India.
Nirmal Kumar LohiyaSchool of Life Sciences, University of Rajasthan, Jaipur, India.
Irina Yu GoryachevaDepartment of General and Inorganic Chemistry, Saratov State University, Saratov, Russian Federation.
Pradyumna Kumar MishraDepartment of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India. pkm_8bh@yahoo.co.uk.ORCID http://orcid.org/0000-0002-0795-2819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineered immune cells offer a prime therapeutic alternate for some aggressive and frequently occurring malignancies like lung cancer. These therapies were reported to result in tumor regression and overall improvement in patient survival. However, studies also suggest that the presence of cancer cell-induced immune-suppressive microenvironment, off-target toxicity, and difficulty in concurrent imaging are some prime impendent in the success of these approaches. The present article reviews the need and significance of the currently available immune cell-based strategies for lung cancer therapeutics. It also showcases the utility of incorporating nanoengineered strategies and details the available formulations of nanocarriers. In last, it briefly discussed the existing methods for nanoparticle fuctionalization and challenges in translating basic research to the clinics. Graphical Abstract.

Indexed as

Cell EngineeringImmunotherapyLung NeoplasmsHumansTumor MicroenvironmentCancer therapeuticsCAR-T-cellsDendritic cellsNanoengineeringNK-cells

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.