Evidence map›Paper›PMID 32172183›Full record

ReviewCurrent opinion in microbiology2020

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms.

Jakub M Kwiecinski, Alexander R Horswill

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 2 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Staphylococcus aureus-vascular endothelium interactions: Mechanisms and therapeutic opportunities.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  6. Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026
    Review
  7. Intraspecific diversity ofMicrobiology spectrum · 2026
    Article
  8. Article
  9. Article
  10. Susceptibility ofAntibiotics (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Detection ofVeterinary sciences · 2026
    Article
  13. Article
  14. Metabolic reprogramming promotesMicrobiology (Reading, England) · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jakub M KwiecinskiDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, USA; Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, USA. Electronic address: alexander.horswill@cuanschutz.edu.
University of Colorado Denver · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
Regulation of Staphylococcus aureus colonization and diseaseR01AI141490 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HORSWILL, ALEXANDER R · 2019 to 2022
$1.5M
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI141490
6 · The paper itself

Abstract

Staphylococcus aureus is an opportunistic pathogen that normally colonizes the human anterior nares. At the same time, this pathogen is one of the leading causes of life-threatening bloodstream infections, such as sepsis and endocarditis. In this review we will present the current understanding of the pathogenesis of these invasive infections, focusing on the mechanisms of S. aureus clearance from the bloodstream by the immune system, and how this pathogen hijacks the host defense and coagulation systems and further interacts with the blood vessel endothelium. Additionally, we will delve into the regulatory mechanisms S. aureus employs during an invasive infection. These new insights into host-pathogen interactions show promising avenues for the development of novel therapies for treating bloodstream infections.

Indexed as

AnimalsBacteremiaHost-Pathogen InteractionsHumansStaphylococcal InfectionsStaphylococcus aureusVirulence

Identifiers

PMID32172183
PMCPMC7244392
OpenAlexW3011668159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.