Trial reportNeuroImage. Clinical2020
PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract.
Trial report in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The research focus and frontiers in surgical treatment of essential tremor.Frontiers in neurology · 2024Pooled it
- Dual-target VIM-PSA deep brain stimulation using octopolar electrodes: surgical technique and feasibility study.Frontiers in neurology · 2026Trial
- Deep brain stimulation for arm tremor: one-year blinded follow-up of a randomized trial.Neurological research and practice · 2026Article
- Patient-Reported Feedback in Essential Tremor Deep Brain Stimulation: Distinguishing Perceived Comfort from Tremor Suppression.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Subthalamic nucleus deep brain stimulation connectivity related to apathy outcomes in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Rescue deep brain stimulation for recurrent essential tremor after ventral intermediate nucleus thalamotomy: illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- Patient-Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Rescue Thalamotomy for Habituation to Deep Brain Stimulation in Essential Tremor: Case Report.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- How accurate is probabilistic tractography when used to predict the "sweet spot" in deep brain stimulation? Mind the gap!Acta neurochirurgica · 2025Article
- Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.Movement disorders clinical practice · 2025Review
- Deep Brain Stimulation: Mechanisms, Cost-Effectiveness, and Precision Applications Across Neurology and Psychiatry.Biomedicines · 2025Review
- Successful Treatment of a Patient With Tremors and Extensive Brain Lesions Using Posterior Subthalamic Area-Deep Brain Stimulation.Journal of movement disorders · 2025Article
- Long-Term Benefit of Thalamic Deep Brain Stimulation in POLR3A Mutation-Associated Action Tremor.Movement disorders clinical practice · 2025Article
- Posterior Subthalamic Area Deep Brain Stimulation Combined with Spinal Cord Stimulation in a Patient with Spinocerebellar Ataxia Type 12.Movement disorders clinical practice · 2025Article
- Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025Review
- Microstructural abnormalities of the dentato-rubro-thalamo-cortical tract in tremor dominant Parkinson's disease and essential tremor plus syndrome.Neuroradiology · 2025Article
- Pathological beta power increase in the subthalamic nucleus is absent in essential tremor.Brain communications · 2025Article
- Multimodal neuroimaging to characterize symptom-specific networks in movement disorders.NPJ Parkinson's disease · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET).
methodsTremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated.
resultsPSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRTT was related to lower amplitudes (p < 0.001) and higher DBS efficiency (p = 0.017).
conclusionsDifferences in tremor outcome and stimulation parameters between contacts in the PSA and the VIM can be explained by their different distance to the DRTT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.