ArticleBritish journal of anaesthesia2020
Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults.
Article in British journal of anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Exploring the gut microbiome-Postoperative Cognitive Dysfunction connection: Mechanisms, clinical implications, and future directions.Brain, behavior, & immunity - health · 2024Review
- Genotype- and sex-specific changes in vital parameters during isoflurane anesthesia in a mouse model of Alzheimer's disease.Frontiers in medicine · 2024Article
- The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap.Molecular neurodegeneration · 2023Review
- Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study.British journal of anaesthesia · 2023Article
- Association of Indication for Hospitalization With Subsequent Amyloid Positron Emission Tomography and Magnetic Resonance Imaging Biomarkers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Perioperative Brain Health in the Older Adult: A Patient Safety Imperative.Anesthesia and analgesia · 2022Review
- Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppMolecular brain · 2022Article
- Isoflurane has no effect on cognitive or behavioral performance in a mouse model of early-stage Alzheimer's disease.Frontiers in neuroscience · 2022Article
- Brain MRI after critical care admission: A longitudinal imaging study.Journal of critical care · 2021Article
- Stress Granules Modulate SYK to Cause Tau-Associated Neurocognitive Deterioration in 5XFAD Mouse After Anesthesia and Surgery.Frontiers in aging neuroscience · 2021Article
- Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.PloS one · 2020Article
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14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to surgery with general anaesthesia (surgery/GA) is associated with cortical atrophy, but the aetiology remains unknown. Amyloid-β (Aβ) deposition is one of the hallmark pathological characteristics of Alzheimer's disease (AD). We examined brain Aβ burden in study participants exposed to surgery/GA.
methodsWe performed a cross-sectional analysis of residents of Olmsted County, MN, USA, in the Mayo Clinic Study of Aging who were aged 70-97 yr and underwent measurement of (i) brain Aβ with Pittsburgh compound B positron emission tomography (PiB PET), (ii) brain glucose metabolism with 18-fluorodeoxyglucose (FDG) PET, and (iii) temporal cortical thickness with MRI. Separate analyses were performed with exposure to surgery/GA, defined as occurring after age 40 yr, and with exposure to surgery/GA, defined as occurring within 20 yr before neuroimaging. Imaging measurements were compared between participants who were exposed to surgery/GA vs not exposed.
resultsOf the 2563 participants, 585 had PET scans. Regardless of the definition used to quantify exposure, no significant associations were detected between exposure and either global PiB PET or FDG PET. In contrast, exposure to surgery/GA was associated with an increased likelihood of abnormal cortical thinning: odds ratio (OR)=1.98 (95% confidence interval [CI]: 1.19-3.31); P=0.010 in those exposed after age 40 yr, and OR=1.64 (95% CI: 1.05-2.55); P=0.029 in those exposed in the prior 20 yr.
conclusionsExposure to surgery/GA is not associated with increases in cortical amyloid deposition. This finding suggests that the modest cortical thinning associated with surgery/GA is not related to AD pathology, but rather is caused by other processes.
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