Evidence map›Paper›PMID 32171317›Full record

ArticleJournal of neuroinflammation2020

A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer's disease.

Kritleen K Bawa, Saffire H Krance, Nathan Herrmann, Hugo Cogo-Moreira, Michael Ouk, Di Yu, Che-Yuan Wu, Sandra E Black, Krista L Lanctôt, Walter Swardfager and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
  7. Article
  8. Review
  9. Myeloperoxidase as a therapeutic target for oxidative damage in Alzheimer's disease.Journal of enzyme inhibition and medicinal chemistry · 2025
    Review
  10. Review
  11. Targeting dysregulated CB1 receptors in a Down syndrome mouse model improves neurological outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Kritleen K BawaDepartment of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Saffire H KranceSchulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON, N6A 5C1, Canada.
Nathan HerrmannHurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Hugo Cogo-MoreiraDepartamento Psichiatria, Universidade Federal de São Paulo, 1, R. Borges Lagoa, 570-Vila Clementino, Sao Paulo, SP, 04038-000, Brazil.
Michael OukDepartment of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Di YuHurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Che-Yuan WuDepartment of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Sandra E BlackHurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Krista L LanctôtDepartment of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Walter SwardfagerDepartment of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. w.swardfager@utoronto.ca.ORCID http://orcid.org/0000-0002-0030-8908
Alzheimer’s Disease Neuroimaging Initiative
Sunnybrook Health Science Centre · CAWestern University · CA

Funding

Alzheimer's Association AARG501466Alzheimer's Association (US) N/AAlzheimer's Research UK N/ABrain Canada AARG501466Michael J. Fox Foundation N/ASunnybrook Research Institute N/AWeston Brain Institute N/A
6 · The paper itself

Abstract

backgroundStudies suggest a role of the innate immune system, including the activity of neutrophils, in neurodegeneration related to Alzheimer's disease (AD), but prospective cognitive data remain lacking in humans. We aimed to investigate the predictive relationship between neutrophil-associated inflammatory proteins in peripheral blood and changes in memory and executive function over 1 year in patients with AD.

methodsParticipants with AD were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neutrophil gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), interleukin-8 (IL-8), macrophage inflammatory protein-1 beta (MIP-1β), and tumor necrosis factor (TNF) were assayed by luminex immunofluorescence multiplex assay at baseline. Confirmatory factor analysis was used to test an underlying neutrophil associated plasma inflammatory factor. Composite z-scores for memory and executive function were generated from multiple tests at baseline and at 1 year. A multiple linear regression model was used to investigate the association of the baseline inflammatory factor with changes in memory and executive function over 1 year.

resultsAmong AD patients (n = 109, age = 74.8 ± 8.1, 42% women, Mini Mental State Examination [MMSE] = 23.6 ± 1.9), the neutrophil-related inflammatory proteins NGAL (λ = 0.595, p < .001), MPO (λ = 0.575, p < .001), IL-8 (λ = 0.525, p < .001), MIP-1β (λ = 0.411, p = .008), and TNF (λ = 0.475, p < .001) were found to inform an underlying factor. Over 1 year, this inflammatory factor predicted a decline in executive function (β = - 0.152, p = 0.015) but not memory (β = 0.030, p = 0.577) in models controlling for demographics, brain atrophy, white matter hyperintensities, the ApoE ε4 allele, concomitant medications, and baseline cognitive performance.

conclusionsAn inflammatory factor constructed from five neutrophil-related markers in peripheral blood predicted a decline in executive function over 1 year in people with mild AD.

Indexed as

Executive FunctionAgedAged, 80 and overAlzheimer DiseaseBiomarkersChemokine CCL4Disease ProgressionFemaleHumansInflammationInterleukin-8Lipocalin-2MaleMiddle AgedNeutrophilsPeroxidaseBiomarkersChemokine CCL4Interleukin-8LCN2 protein, humanLipocalin-2MPO protein, humanPeroxidaseTumor Necrosis Factor-alphaAlzheimer’s diseaseExecutive functionInflammationInterleukin-8Macrophage inflammatory protein-1 betaMemoryMyeloperoxidaseNeutrophilNeutrophil gelatinase-associated LipocalinTumor necrosis factor

Identifiers

PMID32171317
PMCPMC7071641
OpenAlexW3012324410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.