ArticleBMC pregnancy and childbirth2020
Early diagnostic test for acute fatty liver of pregnancy: a retrospective case control study.
Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Liver Biopsy During Pregnancy: A Review.Cureus · 2025Review
- Risk factors for acute fatty liver of pregnancy complicated by acute liver failure: a retrospective study of 133 cases.BMC pregnancy and childbirth · 2025Article
- Acute fatty liver disease in full-term pregnancy: a case report and review of the literature.Journal of medical case reports · 2025Review
- [Acute fatty liver of pregnancy with severe coagulopathy: a case report and review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- Liver imaging and pregnancy: what to expect when your patient is expecting.Insights into imaging · 2024Review
- Key Components of Successful Management of Acute Fatty Liver of Pregnancy: A Case Report and Literature Review.Cureus · 2024Article
- A Case Report on Acute Fatty Liver of Pregnancy: A Difficult Differential Diagnosis of Liver Disorder.Cureus · 2023Article
- The assessment in patients with acute fatty liver of pregnancy (AFLP) treated with plasma exchange: a cohort study of 298 patients.BMC pregnancy and childbirth · 2023Article
- Role of Plasmapheresis in Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome.Cureus · 2023Article
- A 24-Year-Old Woman Presenting in the Third Trimester of Pregnancy with Nausea, Vomiting, and Abdominal Pain and Diagnosed with Acute Fatty Liver of Pregnancy.The American journal of case reports · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly diagnosis is important to lower the mortality rate of acute fatty liver of pregnancy (AFLP). The Swansea criteria is commonly used to diagnose AFLP, but some terms could only be reached when symptoms and signs have progressed, or are not efficient in clinical practice. Therefore, it is necessary to select cost effective tests to simplify and facilitate early suspicion of acute fatty liver of pregnancy.
methodsThis is a retrospective study of 28,800 medical records at the Second Xiangya Hospital from 2009 to 2015, including 41 patients with AFLP and 172 other diseases that could show similar symptoms to AFLP. The evaluated variables included past history of liver diseases, blood pressure, gastrointestinal symptoms, blood count, liver function test, coagulation function test and blood sugar test. The sensitivity, specificity, positive predict value and negative predict value were calculated for models in diagnosing AFLP.
resultsThe significant variables associated with AFLP included gastrointestinal symptoms, blood pressure > 140/90 mmHg, aminotransferase> 42 IU/l, total bilirubin> 0.8 mg/dl, total bilirubin acid> 10.0 μmol/L, activated partial prothrombin time(APTT) > 34 s, prothrombin time(PT) > 14 s, white blood cells> 11 *10
conclusionsApplication of a statistical model including maternal symptoms, biochemical and haematological parameters has high diagnostic accuracy for earlier identification of AFLP. However, this finding needs to be tested in another cohort to determine whether this statistical model has the same performance.
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