Evidence map›Paper›PMID 32171279›Full record

ArticleBMC public health2020

Factors associated with 36-month loss to follow-up and mortality outcomes among HIV-infected adults on antiretroviral therapy in Central Kenya.

Paul Wekesa, Angela McLigeyo, Kevin Owuor, Jonathan Mwangi, Evelyne Nganga, Kenneth Masamaro

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In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul WekesaCentre for Health Solutions, Nairobi, Kenya. pwekesa@chskenya.org.ORCID http://orcid.org/0000-0001-9274-7731
Angela McLigeyoCentre for Health Solutions, Nairobi, Kenya.
Kevin OwuorCentre for Health Solutions, Nairobi, Kenya.
Jonathan MwangiDivision of Global HIV & TB, Centers for Disease Control and Prevention (CDC), Nairobi, Kenya.
Evelyne NgangaCentre for Health Solutions, Nairobi, Kenya.
Kenneth MasamaroDivision of Global HIV & TB, Centers for Disease Control and Prevention (CDC), Nairobi, Kenya.

Funding

U.S. President's Emergency Plan for AIDS Relief NU2GGH002024-01-00
6 · The paper itself

Abstract

backgroundThe scale-up of HIV treatment programs has resulted in a reduction in HIV-related morbidity and mortality. However, retention of patients in these programs remains a challenge in sub-Saharan Africa. Understanding factors associated with loss to follow-up (LTFU) and mortality outcomes is therefore important to inform targeted program interventions.

methodsA retrospective multi-cohort analysis of 23,890 adult patients on ART over 36 months of follow-up in Kenya was done. Multivariate logistic regression analysis was done to assess for factors associated with LTFU and mortality at 6, 12, 24, and 36 months of follow-up.

resultsMajority, 67.7%, were female. At 36 months, 27.2% were LTFU and 13.5% had died. Factors associated with mortality at 36 months included older age (51 years and above) using 20-35 years as reference [(adjusted odds ratio [aOR], 1.51, 95% confidence interval (CI) 1.23-1.86, p < 0.001], being male (aOR, 1.59, 95% CI 1.39-1.83, p < 0.001), divorced using married as reference (aOR, 1.86, 95% CI 1.56-2.22, p < 0.001), having a body mass index (BMI) score of less than 18.5 kg/m

conclusionsFactors associated with LTFU and mortality were generally similar over time. Implementation of programs in similar settings should be tailored to gender, age profiles, nutritional, and, marital status of patients to address LTFU. In addition, programs should focus on the care of older patients to reduce the risk of mortality.

Indexed as

Lost to Follow-UpAdultAge FactorsAnti-Retroviral AgentsFemaleHIV InfectionsHumansKenyaMaleMarital StatusMiddle AgedRetrospective StudiesRisk FactorsSex FactorsTreatment OutcomeYoung AdultAnti-Retroviral AgentsAntiretroviral therapyHIVKenyaLoss to follow-upMortality

Identifiers

PMID32171279
PMCPMC7071670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.