Evidence map›Paper›PMID 32171272›Full record

ArticleBMC medical genetics2020

SLC1A3 C3590T but not BDNF G196A is a predisposition factor for stress as well as depression, in an adolescent eastern Indian population.

Madhumita Ghosh, Akhtar Ali, Shobhna Joshi, Adya Shankar Srivastava, Madhu G Tapadia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Madhumita GhoshCytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India.
Akhtar AliCentre for Genetic Disorders, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.
Shobhna JoshiDepartment of Psychology, Faculty of Arts, Banaras Hindu University, Varanasi, 221005, India.
Adya Shankar SrivastavaDepartment of Psychiatry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Madhu G TapadiaCytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India. madhu@bhu.ac.in.ORCID 0000-0001-9763-2634
Banaras Hindu University · INInstitute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescence is a distinctive stage of various changes and is noted as peak age for onset of many psychiatric disorders, especially linked to stress and depression. Several genetic variations are being increasingly known to be linked with stress and depression. The polymorphisms in two such genes, the BDNF and SLC1A3, have been reported to be linked with either depression/stress or with suicidal behaviour. These genes have not been validated in Indian population, and therefore there is a need to investigate these genes in Indian population. The present study was undertaken to test whether the known polymorphisms SLC1A3 C3590T, SLC1A3 C869G and BDNF G196A are associated or not with stress or depression in an eastern Indian population.

methodsA case-control association study was performed with 108 cases having variable levels of stress and depression and 205 matched controls. Detection of stress and depression was done by using standard instruments as PSS and CES-D, respectively and demographic profile was obtained for each individual on the basis of personal data sheet. Genotyping for the selected polymorphisms was performed by PCR followed by restriction digestion.

resultsThe SNP SLC1A3 C3590T was found to be associated with stress and depression (p = 0.0042, OR = 2.072). Therefore, the T allele increases the risk by more than two folds for stress and depression in the present population. The other allele of SLC1A3, G869C, as well as BDNF G196A were not associated with stress or depression in the population studied.

conclusionSLC1A3 C3590T is a predisposition factor for stress and depression in an eastern Indian population, whereas SLC1A3 G869C and BDNF G196A were not found to be a risk factor. Therefore, presence of T allele of SLC1A3 C3590T, may predict the development of stress and depression in an individual. This may also help in the understanding of pathophysiology of the disease. However, these findings warrant a wider study in Indian populations and would be of significance in understanding the predisposition of stress and depression in this population.

Indexed as

Polymorphism, Single NucleotideAdolescentAsian PeopleBrain-Derived Neurotrophic FactorCase-Control StudiesDepressionExcitatory Amino Acid Transporter 1FemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansIndiaMalePsychology, AdolescentRisk FactorsStress, PsychologicalBDNF protein, humanBrain-Derived Neurotrophic FactorExcitatory Amino Acid Transporter 1SLC1A3 protein, humanAdolescentBDNFDepressionIndiaPolymorphismSLC1A3Stress

Identifiers

PMID32171272
PMCPMC7071583
OpenAlexW3011652983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.