ArticleBMC genetics2020
Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle.
Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
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- Single- and Multi-Trait GWASs Combined with Genetic Parameter Estimation Reveal Candidate Genes for Body Conformation Traits in Sika Deer (Animals : an open access journal from MDPI · 2026Article
- Analysis of the characteristics of rumen microorganisms and their metabolites and plasma metabolites in crossbred beef cattle at different stages.Veterinary research communications · 2026Article
- Large deletions in the DNA primase large subunit PRIM2 are associated with NADP-malate dehydrogenase activity in a porcine FAnimal genetics · 2026Article
- Genome-wide association study of the reproductive, body size, and carcass-related latent and directly measured traits in admixed beef heifers.Frontiers in genetics · 2026Article
- Decoding the DNA of Anatolian water buffalo by genome-wide discoveries for body size and ultrasound carcass traits.BMC veterinary research · 2025Article
- Investigation of the genetic determinism of amino acid digestibility traits in Duroc×Landrace×Yorkshire crossbred pigs.Animal bioscience · 2025Article
- Large-scale genome-wide association analysis reveals candidate genes in yak body size traits.BMC genomics · 2025Article
- Integrated unmanned aerial vehicle-based LiDAR and RGB data for individual cattle growth monitoring in precision livestock farming.Scientific data · 2025Article
- Genomic Selection for Economically Important Traits in Dual-Purpose Simmental Cattle.Animals : an open access journal from MDPI · 2025Article
- Identification of regulatory loci and candidate genes related to body weight traits in broilers based on different models.BMC genomics · 2025Article
- Whole genome and transcriptome analyses identify genetic markers associated with growth traits in Qinchuan black pig.BMC genomics · 2025Article
- Understanding molecular mechanisms of vertebral number of variations on Mongolian sheep using candidate genes analysis.Animal bioscience · 2025Article
- Unveiling Genetic Potential for Equine Meat Production: A Bioinformatics Approach.Animals : an open access journal from MDPI · 2024Article
- Beef Cattle Genome Project: Advances in Genome Sequencing, Assembly, and Functional Genes Discovery.International journal of molecular sciences · 2024Review
- Whole-genome sequencing reveals genomic diversity and selection signatures in Xia'nan cattle.BMC genomics · 2024Article
- Genetic legacy and adaptive signatures: investigating the history, diversity, and selection signatures in Rendena cattle resilient to eighteenth century rinderpest epidemics.Genetics, selection, evolution : GSE · 2024Article
- Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep.Parasites & vectors · 2024Article
- Identification of Heilongjiang crossbred beef cattle pedigrees and reveals functional genes related to economic traits based on whole-genome SNP data.Frontiers in genetics · 2024Article
- Genome-Wide Association Study for Test-Day Milk Yield, Proteins, and Composition Traits of Crossbred Dairy Cattle in Ethiopia.International journal of genomics · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBody size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We performed genome-wide association studies (GWAS) of these traits over the course of three growth stages (6, 12 and 18 months after birth) using three statistical models, single-trait GWAS, multi-trait GWAS and LONG-GWAS. The Illumina Bovine HD 770 K BeadChip was used to identify genomic single nucleotide polymorphisms (SNPs) in 1217 individuals.
resultsIn total, 19, 29, and 10 significant SNPs were identified by the three models, respectively. Among these, 21 genes were promising candidate genes, including SOX2, SNRPD1, RASGEF1B, EFNA5, PTBP1, SNX9, SV2C, PKDCC, SYNDIG1, AKR1E2, and PRIM2 identified by single-trait analysis; SLC37A1, LAP3, PCDH7, MANEA, and LHCGR identified by multi-trait analysis; and P2RY1, MPZL1, LINGO2, CMIP, and WSCD1 identified by LONG-GWAS.
conclusionsMultiple association analysis was performed for six growth traits at each growth stage. These findings offer valuable insights for the further investigation of potential genetic mechanism of growth traits in Simmental beef cattle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.