Evidence map›Paper›PMID 32170839›Full record

ArticleObesity (Silver Spring, Md.)2020

Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.

Nicole L Mihalopoulos, Jeffrey T Yap, Britney Beardmore, Richard Holubkov, M Nazeem Nanjee, John M Hoffman

Open access · greenAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicole L MihalopoulosDivision of Adolescent Medicine, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-7933-4120
Jeffrey T YapCenter for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Britney BeardmoreCenter for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Richard HolubkovDivision of Critical Care Medicine, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
M Nazeem NanjeeDepartment of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA.
John M HoffmanCenter for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
University of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Changes in Adipokines and Adiposity during Puberty and Young AdulthoodK23HL092069 · NHLBI · UNIVERSITY OF UTAH · PI MIHALOPOULOS, NICOLE LENORE · 2010 to 2014
$713k
Huntsman Cancer Institute 3Huntsman Cancer Institute 5NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1TR001067NCATS NIH HHS UL1 TR002538NHLBI NIH HHS HL#092069NHLBI NIH HHS K23 HL092069NIH HHSUniversity of Utah
6 · The paper itself

Abstract

objectiveThis study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that the clinical implications of these findings remain uncertain.

methodsTwenty-one females and twenty-three males with obesity (BMI ≥ 30 kg/m

resultsCold-activated BAT was identified in 43% of participants (11 female, 8 male); females had greater

conclusionsA high prevalence of cold-activated BAT was found in the study participants. BAT could be important in decreasing metabolic dysfunction among young adults with obesity, making it a potential target for treating metabolically unhealthy obesity.

Indexed as

Adipose Tissue, BrownAdolescentAdultCardiovascular DiseasesFemaleFluorodeoxyglucose F18HumansMaleObesityPositron Emission Tomography Computed TomographyYoung AdultFluorodeoxyglucose F18

Identifiers

PMID32170839
PMCPMC7180112
OpenAlexW3010737400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.