Evidence map›Paper›PMID 32170487›Full record

ArticleClinical rheumatology2020

Persistent chikungunya arthritis in Roraima, Brazil.

Ramão Luciano Nogueira Hayd, Maony Rodrigues Moreno, Felipe Naveca, Richard Amdur, Karol Suchowiecki, Hugh Watson, Gary S Firestein, Gary Simon, Aileen Y Chang

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Duration of Fever in Patients with Dengue: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ramão Luciano Nogueira HaydLaboratorio de Parasitologia e Vetores da Amazonia, Curso de Enfermagem, Centro de Ciencias da Saude, Universidade Federal de Roraima, Boa Vista, RR, Brazil.
Maony Rodrigues MorenoLaboratorio de Parasitologia e Vetores da Amazonia, Curso de Enfermagem, Centro de Ciencias da Saude, Universidade Federal de Roraima, Boa Vista, RR, Brazil.
Felipe NavecaLaboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, FIOCRUZ, Manaus, Brazil.
Richard AmdurDepartment of Surgery, George Washington University, Washington, DC, USA.
Karol SuchowieckiDepartment of Medicine, George Washington University, 2150 Pennsylvania Ave Suite 5-416, Washington, DC, 20037, USA.
Hugh WatsonEvotec ID, Lyon, France.
Gary S FiresteinDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Gary SimonDepartment of Medicine, George Washington University, 2150 Pennsylvania Ave Suite 5-416, Washington, DC, 20037, USA.
Aileen Y ChangDepartment of Medicine, George Washington University, 2150 Pennsylvania Ave Suite 5-416, Washington, DC, 20037, USA. chang@email.gwu.edu.
George Washington University · USUniversidade Federal de Roraima · BRFundação Oswaldo Cruz · BRUniversity of California, San Diego · US

Funding

Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS KL2-TR-001877
6 · The paper itself

Abstract

backgroundThe Amazon region of Brazil experienced a large epidemic of East Central South African (ECSA) chikungunya virus (CHIKV) in 2017 and continuous transmission of CHIKV persists. The impact of chronic arthritis caused by ECSA CHIKV is unknown.

objectiveThe study aim was to describe the duration, severity, and characteristics of CHIKV arthritis in Roraima, Brazil, in comparison with local controls to further understand the long-term rheumatologic impact of ECSA CHIKV infection.

methodsWe performed a cross-sectional analysis comparing clinical arthritis outcomes among 40 cases with chronic (> 3 months) arthritis attributed to their CHIKV disease (n = 40) with control participants who were exposed to CHIKV but did not develop chronic arthritis (n = 40), rheumatoid arthritis controls (n = 40), and healthy controls lacking CHIKV exposure and arthritis (n = 40).

findingsOur primary finding is that over 2 years post-infection, patients report moderate arthritis disease severity comparable with rheumatoid arthritis with the most significant impact on decreased quality of life from pain. MAIN

conclusionsThese findings suggest that chronic arthritis caused by ECSA CHIKV infection has had a moderate impact in the Americas. Key Points • Chikungunya infection is responsible for moderate arthritis disease severity. • The East Central South African (ECSA) strain of CHIKV is a cause of persistent arthritis in Roraima, Brazil.

Indexed as

ArthritisChikungunya FeverAmericasBrazilCross-Sectional StudiesHumansPhylogenyQuality of LifeAmazon regionChikungunyaRheumatoid arthritis

Identifiers

PMID32170487
OpenAlexW3011363587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.