Evidence map›Paper›PMID 32170450›Full record

ArticleVirchows Archiv : an international journal of pathology2020

Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing.

Ya Lu, Xin He, Yan Qiu, Huijiao Chen, Hua Zhuang, Jin Yao, Hongying Zhang

Erratum issuedAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Intravascular fasciitis of the common femoral vein mimicking deep venous thrombosis.Journal of vascular surgery cases and innovative techniques · 2026
    Article
  2. Review
  3. Review
  4. Intravascular fasciitis of the scalp as a complication of ICP monitor placement: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  5. Review
  6. Article
  7. Detection of sarcoma fusions by a next-generation sequencing based-ligation-dependent multiplex RT-PCR assay.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  8. Article
  9. Frontiers in oncology · 2022
    Article
  10. Atypical nodular fasciitis with a novel PAFAH1B1-USP6 fusion in a 22-month-old boy.Virchows Archiv : an international journal of pathology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Ubiquitin-specific Peptidase 6 (Cancer genomics & proteomics
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ya LuDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
Xin HeDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
Yan QiuDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
Huijiao ChenDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
Hua ZhuangDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jin YaoDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Hongying ZhangDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China. hy_zhang@scu.edu.cn.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

National Natural Science Foundation of China 81472510National Natural Science Foundation of China 81972520West China Hospital, Sichuan University 2018HXFH011
6 · The paper itself

Abstract

Intravascular fasciitis (IVF) is considered a rare variant of nodular fasciitis, which often involves small- and medium-sized blood vessels. Approximately 43 cases of IVF have been reported in the English literature to date. Here, we report an IVF case arising from the common iliac vein of the pelvic cavity in a 19-year-old Chinese man. Histologically, the lesion was confined within the vascular lumen and consisted of regular myofibroblasts immersed in a fibromyxoid stroma. The tumor cells showed a USP6 rearrangement by fluorescence in situ hybridization but were negative for MYH9-USP6 fusion by reverse transcription polymerase chain reaction. Subsequent next-generation sequencing identified the CTNNB1-USP6 fusion. To the best of our knowledge, the vessel involved in this case is the largest vein among the reported cases. The present case might be the first example of a USP6-rearranged lesion in this entity, suggesting that IVF should be included in the USP6-induced family.

Indexed as

Asian Peoplebeta CateninFasciitisFibromaGene RearrangementHigh-Throughput Nucleotide SequencingHumansIn Situ Hybridization, FluorescenceMaleMyofibroblastsProto-Oncogene ProteinsUbiquitin ThiolesteraseYoung Adultbeta CateninCTNNB1 protein, humanProto-Oncogene ProteinsUbiquitin ThiolesteraseUSP6 protein, humanCTNNB1-USP6Intravascular fasciitisNext-generation sequencingNodular fasciitisUSP6-induced neoplasmUSP6 rearrangement

Identifiers

PMID32170450
OpenAlexW3010650268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.