ArticleApplied microbiology and biotechnology2020
The transmembrane protein MaSho1 negatively regulates conidial yield by shifting the conidiation pattern in Metarhizium acridum.
Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Insight into the role of Sho1 in high-hydrostatic pressure and oxidative stress adaptation of the hadal fungusApplied and environmental microbiology · 2026Article
- MaMsb2, a signaling mucin, is involved in conidiation, stress tolerances, and virulence in the entomopathogenic fungusVirulence · 2025Article
- An Integrative Multi-Source Evidence Framework for Prioritizing Virulence-Associated Pathways inGenes · 2025Article
- MaPom1, a Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase, Positively Regulates Thermal and UV-B Tolerance inInternational journal of molecular sciences · 2024Article
- Comparative Transcriptomic Analyses Propose the Molecular Regulatory Mechanisms Underlying 1,8-Cineole fromMolecules (Basel, Switzerland) · 2023Review
- MaNCP1, a C2H2 Zinc Finger Protein, Governs the Conidiation Pattern Shift through Regulating the Reductive Pathway for Nitric Oxide Synthesis in the Filamentous Fungus MetarhiziumMicrobiology spectrum · 2022Article
- Host-Pathogen Interactions betweenJournal of fungi (Basel, Switzerland) · 2022Review
- MaOpy2, a Transmembrane Protein, Is Involved in Stress Tolerances and Pathogenicity and Negatively Regulates Conidial Yield by Shifting the Conidiation Pattern inJournal of fungi (Basel, Switzerland) · 2022Article
- MaSln1, a Conserved Histidine Protein Kinase, Contributes to Conidiation Pattern Shift Independent of the MAPK Pathway inMicrobiology spectrum · 2022Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sho1 is an important membrane sensor upstream of the HOG-MAPK signaling pathway, which plays critical roles in osmotic pressure response, growth, and virulence in fungi. Here, a Sho1 homolog (MaSho1), containing four transmembrane domains and one Src homology (SH3) domain, was characterized in Metarhizium acridum, a fungal pathogen of locusts. Targeted gene disruption of MaSho1 impaired cell wall integrity, virulence, and tolerances to UV-B and oxidative stresses, while none of them was affected when the SH3 domain was deleted. Intriguingly, disruption of MaSho1 significantly increased conidial yield, which was not affected in the SH3 domain mutant. Furthermore, it was found that deletion of MaSho1 led to microcycle conidiation of M. acridum on the normal conidiation medium. Deletion of MaSho1 significantly shortened the hyphal cells but had no effect on conidial germination. Digital gene expression profiling during conidiation indicated that differential expression of genes was associated with mycelial development, cell division, and differentiation between the wild type and the MaSho1 mutant. These data suggested that disruption of MaSho1 shifted the conidiation pattern by altering the transcription of genes to inhibit mycelial growth, thereby promoting the conidiation of M. acridum.
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