Evidence map›Paper›PMID 32170370›Full record

ArticleWorld journal of surgery2020

Predictors and Survival of Patients with Osteosarcoma After Limb Salvage versus Amputation: A Population-Based Analysis with Propensity Score Matching.

Lin Qi, Xiaolei Ren, Zhongyue Liu, Shuangqing Li, Wenchao Zhang, Ruiqi Chen, Congzhou Chen, Chao Tu, Zhihong Li

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In one paragraph

Article in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  3. Observational
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  5. PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lin QiDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaolei RenDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhongyue LiuDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Shuangqing LiDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Wenchao ZhangDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Ruiqi ChenDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Congzhou ChenXiangya School of Nursing, Central South University, Changsha, China.
Chao TuDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China. tuchao@csu.edu.cn.
Zhihong LiDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China. lizhihong@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConflicting findings have been reported concerning the survival of patients treated with limb salvage and amputation for osteosarcoma. This study aimed to identify predictors associated with surgery types and survival difference.

methodsPatients with osteosarcoma were selected from the Surveillance Epidemiology and End Results database (1975-2016). Multivariable logistic regression analysis was conducted, and a nomogram was further established. Propensity score matching (PSM)-adjusted Kaplan-Meier curves, log-rank tests, Cox proportional hazards regression analysis were performed to compare overall survival (OS) and cancer-specific survival (CSS).

resultsAmong 3363 patients with osteosarcoma, 2447 and 916 underwent limb salvage and amputation. Predictors associated with amputation in the nomogram included age, gender, primary tumor site, tumor grade, tumor stage, tumor size and radiotherapy. Totally 900 pairs of patients treated with limb salvage and amputation were matched after PSM. Limb salvage was significantly associated with improved OS (HR, 0.773; 95% CI, 0.670-0.892; p < 0.001) and CSS (HR, 0.795; 95% CI, 0.681-0.927; p = 0.003) in PSM-adjusted cohort after adjusting for related variables. The significant treatment effect of limb salvage was consistent within most subgroups. Among patients treated with surgery for osteosarcoma, age between 41 and 60, age ≥ 61, pelvis as the primary site, high tumor grade (III/IV), regional and distant tumor stage, tumor size ≥ 92 mm and radiotherapy were independent prognostic factors in PSM cohort.

conclusionsLimb salvage exhibits significant benefit on OS and CSS compared with amputation for osteosarcoma. Predicators and survival differences should be given full consideration for the treatment of osteosarcoma.

Indexed as

Propensity ScoreAdolescentAdultAgedAmputation, SurgicalBone NeoplasmsFemaleHumansLimb SalvageLogistic ModelsMaleMiddle AgedOsteosarcomaYoung AdultAmputationLimb salvageOsteosarcomaPropensity score matchingSEER database

Identifiers

PMID32170370
OpenAlexW3011370460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.