ArticleThe international journal of neuropsychopharmacology2020
Brain Functional Connectivity Correlates of Response in the 7.5% CO2 Inhalational Model of Generalized Anxiety Disorder: A Pilot Study.
Article in The international journal of neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The effects of transcranial direct current stimulation (tDCS) on subjective, autonomic and neuropsychological response in the 7.5% COJournal of psychopharmacology (Oxford, England) · 2026Trial
- Verbal and Visuospatial Working Memory Performance During the COHuman psychopharmacology · 2026Trial
- Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety.The international journal of neuropsychopharmacology · 2024Trial
- Article
- Characterising the anxiogenic network from functional connectivity analysis of the COScientific reports · 2024Article
- The impact of anxiety on postural control: COPsychophysiology · 2023Article
- The Association Between Adolescent Residential Mobility and Adult Social Anxiety, BDNF and Amygdala-Orbitofrontal Functional Connectivity in Young Adults With Higher Education.Frontiers in psychiatry · 2020Article
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Authors and funding
5 authors.
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Abstract
backgroundThe 7.5% CO2 inhalational model can be used to explore potential treatments for generalized anxiety disorder. However, it is unknown how inter-individual variability in the functional architecture of negative affective valence systems might relate to anxiogenic response in this model.
methodsA total of 13 healthy volunteers underwent functional magnetic resonance imaging during a passive emotional face perception task. We explored task-evoked functional connectivity in the potential threat system through generalized psychophysiological interaction analysis. Within 7 days, these participants underwent prolonged 7.5% CO2 inhalation, and results from the generalized psychophysiological interaction analysis were correlated with CO2 outcome measures.
resultsFunctional connectivity between ventromedial prefrontal cortex and right amygdala positively correlated with heart rate and subjective anxiety, while connectivity between midcingulate cortex and left amygdala negatively correlated with anxiety during CO2 challenge.
conclusionsResponse to CO2 challenge correlated with task-evoked functional connectivity in the potential threat system. Further studies should assess whether this translates into clinical populations.
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