ArticleScientific reports2020
Cell-bound IgE and plasma IgE as a combined clinical diagnostic indicator for allergic patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review.Frontiers in pharmacology · 2022Pooled it
- IgE based therapeutics are an emerging modality in cancer treatment.Discover oncology · 2025Review
- Global Burden of Allergies: Mechanisms of Development, Challenges in Diagnosis, and Treatment.Life (Basel, Switzerland) · 2025Review
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Development and validation of a nomogram for predicting the efficacy of vidian neurectomy in the treatment of chronic rhinosinusitis with nasal polyps combined with allergic rhinitis.Frontiers in surgery · 2025Article
- Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE.Frontiers in immunology · 2025Article
- Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis.Science translational medicine · 2024Article
- CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy.Clinical reviews in allergy & immunology · 2024Review
- Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.Recent advances in inflammation & allergy drug discovery · 2024Article
- Investigating Forkhead Box O Transcription Factor 1 Gene's Relation to Immunoglobulin E in House Dust Mite-Allergic Asthma Patients.Advances in respiratory medicine · 2023Article
- Antibody-mediated regulation of basophils: emerging views and clinical implications.Trends in immunology · 2023Review
- [Characteristics of allergen component in dust mite-induced allergic rhinitis patients].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- A model to predict a risk of allergic rhinitis based on mitochondrial DNA copy number.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Article
- Increased serum free IgE levels in patients with chronic spontaneous urticaria (CSU).The World Allergy Organization journal · 2022Article
- IgE in the Pathogenesis of SLE: From Pathogenic Role to Therapeutic Target.Antibodies (Basel, Switzerland) · 2020Review
- Biosensors for Detecting Lymphocytes and Immunoglobulins.Biosensors · 2020Review
- Bacterial lysates in allergic rhinitis and chronic rhinosinusitis: Mechanisms and clinical evidence.Science progressReview
- IgE and IgG4 Repertoire in Asymptomatic HDM-Sensitized and HDM-Induced Allergic Rhinitis Patients.International archives of allergy and immunologyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic responses are mainly caused by IgE, which is often located on the cell surface. The current diagnostic method detects both allergen-specific IgE and total IgE levels, but a number of allergic patients have a normal serum IgE level, which is a poor clinical correlate for allergy. Here, we developed a simple method to detect the level of cell-bound IgE by dissociating it from blood cells with lactic acid. Dissociated cell-bound IgE and plasma IgE levels were detected using the same ELISA kit at the same time. We established two clinical cohorts: an allergic patient group and a healthy participant group. In general, cell-bound IgE correlated well with plasma IgE; however, some patients exhibited high cell-bound IgE levels but low plasma IgE levels. We recommended 350 ng/mL peripheral blood total IgE (cell-bound IgE + plasma IgE) as the cut-off value for allergy diagnosis. Using this indicator, 90.32% of our allergic patients were correctly diagnosed. The peripheral blood total IgE level is a promising clinical diagnostic indicator in allergic patients and will provide more guidance for allergy diagnosis and therapeutic evaluation.
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