Evidence map›Paper›PMID 32170008›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart.

Guiling Zhao, Humberto C Joca, Mark T Nelson, W Jonathan Lederer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. FMolecular biology reports · 2023
    Pooled it
  2. Review
  3. Review
  4. Interstitial cells and arrhythmia.American journal of physiology. Cell physiology · 2026
    Review
  5. Article
  6. GLP-1 activates KNature communications · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Electrifying the brain capillary CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Pericytes in mouse heart.Frontiers in physiology · 2025
    Article
  14. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  15. KArhiv za farmaciju · 2024
    Article
  16. Do KFrontiers in immunology · 2024
    Review
  17. Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Guiling ZhaoLaboratory of Molecular Cardiology, Center for Biomedical Engineering and Technology, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201; gzhao@som.umaryland.edu Mark.Nelson@uvm.edu jlederer@som.umaryland.edu.
Humberto C JocaLaboratory of Molecular Cardiology, Center for Biomedical Engineering and Technology, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
Mark T NelsonDepartment of Pharmacology, The University of Vermont, Burlington, VT 05405; gzhao@som.umaryland.edu Mark.Nelson@uvm.edu jlederer@som.umaryland.edu.
W Jonathan LedererLaboratory of Molecular Cardiology, Center for Biomedical Engineering and Technology, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201; gzhao@som.umaryland.edu Mark.Nelson@uvm.edu jlederer@som.umaryland.edu.
University of Maryland, Baltimore · USUniversity of Vermont · US

Funding

Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
NHLBI NIH HHS R01 HL142290NHLBI NIH HHS R35 HL140027NHLBI NIH HHS U01 HL116321NHLBI NIH HHS UM1 HL120877NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

Local control of blood flow in the heart is important yet poorly understood. Here we show that ATP-sensitive K

Indexed as

Adenosine TriphosphateAnimalsCoronary CirculationEndothelial CellsFemaleHeartHeart VentriclesKATP ChannelsMaleMiceMice, TransgenicMuscle, Smooth, VascularMyocytes, CardiacMyocytes, Smooth MusclePotassium Channels, Inwardly RectifyingRatsAdenosine TriphosphateKATP ChannelsPotassium Channels, Inwardly RectifyingATP-sensitive potassium channelcapillaryelectro-metabolic signalingheartpericyte

Identifiers

PMID32170008
PMCPMC7132126
OpenAlexW3010651371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.