Evidence map›Paper›PMID 32169927›Full record

ArticleBMJ open2020

Prediction of gestational age with symphysis-fundal height and estimated uterine volume in a pregnancy cohort in Sylhet, Bangladesh.

Anne C C Lee, Rachel Whelan, Nazmun Nahar Bably, Lauren E Schaeffer, Sayedur Rahman, Salahuddin Ahmed, Syed Mamun Ibne Moin, Nazma Begum, Mohammad Abdul Quaiyum, Bernard Rosner and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01572532 (Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01572532 nacompletednot on this map

Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2010 to 2016Enrolled9,712ConditionsMaternal Infection Affecting NewbornArmsScreening treatment and referral
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Anne C C LeePediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA alee6@bwh.harvard.edu.ORCID 0000-0003-2654-9862
Rachel WhelanPediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nazmun Nahar BablyHealth Section, United Nations Childrens Fund, Rangpur, Bangladesh.
Lauren E SchaefferPediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sayedur RahmanProjahnmo Research Foundation, Dhaka, Bangladesh.
Salahuddin AhmedProjahnmo Research Foundation, Dhaka, Bangladesh.
Syed Mamun Ibne MoinProjahnmo Research Foundation, Dhaka, Bangladesh.
Nazma BegumProjahnmo Research Foundation, Dhaka, Bangladesh.
Mohammad Abdul QuaiyumCentre for Reproductive Health, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Bernard RosnerBiostatistics, Harvard Medical School, Boston, Massachusetts, USA.
James A LitchGlobal Alliance to Prevent Prematurity and Stillbirth (GAPPS), Lynnwood, Washington, USA.
Abdullah H BaquiDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Blair J WylieDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Biomedical Research Foundation · BDBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USGlobal Alliance to Prevent Prematurity and Stillbirth · USInternational Centre for Diarrhoeal Disease Research · BDJohns Hopkins University · USSave the Children · BD

Funding

The Roles of Perinatal Nutrition, Infection and Inflammation in the Neurodevelopment of Bangladeshi InfantsK23HD091390 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, ANNE SHEE CC · 2017 to 2021
$864k
NICHD NIH HHS K23 HD091390
6 · The paper itself

Abstract

objectiveTo improve the accuracy of the prediction of gestational age (GA) before birth with the standardised measurement of symphysis-fundal height (SFH), estimation of uterine volume, and statistical modelling including maternal anthropometrics and other factors.

designProspective pregnancy cohort study.

settingRural communities in Sylhet, Bangladesh.

participants1516 women with singleton pregnancies with early pregnancy ultrasound dating (<20 weeks); 1486 completed follow-up.

methodsSFH and abdominal girth were measured at subsequent antenatal care (ANC) visits by community health workers at 24 to 28, 32 to 36, and/or >37 weeks gestation. An estimated uterine volume (EUV) was calculated from these measures. Data on pregnancy characteristics and other maternal anthropometrics were also collected. PRIMARY OUTCOME MEASURE: GA at subsequent ANC visits, as defined by early ultrasound dating.

results1486 (98%) women had at least one subsequent ANC visit, 1102 (74%) women had two subsequent ANC visits, and 748 (50%) had three visits. Using the common clinical practice of approximating the GA (in weeks) with the SFH measurement (cm), SFH systematically underestimated GA in late pregnancy (mean difference -4.4 weeks, 95% limits of agreement -12.5 to 3.7). For the classification of GA <28 weeks, SFH <26 cm had 85% sensitivity and 81% specificity; and for GA <34 weeks, SFH <29 cm had 83% sensitivity and 71% specificity. EUV had similar diagnostic accuracy. Despite rigorous statistical modelling of SFH, accounting for repeated longitudinal measurements and additional predictors, the best model without including a known last menstrual period predicted 95% of pregnancy dates within ±7.4 weeks of early ultrasound dating.

conclusionsWe were unable to predict GA with a high degree of accuracy before birth using maternal anthropometric measures and other available maternal characteristics. Efforts to improve GA dating in low- and middle-income countries before birth should focus on increasing coverage and training of ultrasonography. TRIAL REGISTRATION NUMBER: NCT01572532.

Indexed as

Diagnostic Techniques, Obstetrical and GynecologicalGestational AgeAdultAnthropometryBangladeshFemaleHumansPregnancyProspective StudiesSensitivity and SpecificityUltrasonography, PrenatalUterusYoung Adultestimated uterine volumegestational agepreterm birthsymphysis fundal heightuterine fundal height

Identifiers

PMID32169927
PMCPMC7069288
OpenAlexW3011424076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.