Evidence map›Paper›PMID 32169913›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET.

Simone Krebs, Darren R Veach, Lukas M Carter, Milan Grkovski, Monica Fornier, Michael J Mauro, Martin H Voss, Daniel C Danila, Eva Burnazi, Manda Null and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Simone KrebsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Darren R VeachDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Lukas M CarterDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Monica FornierDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael J MauroDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Martin H VossDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Daniel C DanilaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Eva BurnaziDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Manda NullDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Kevin StatonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Christina PresslLaboratory of Neural Systems, Rockefeller University, New York, New York.
Bradley J BeattieDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Pat ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Wolfgang A WeberDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Serge K LyashchenkoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Mark P S DunphyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York dunphym@mskcc.org.
Memorial Sloan Kettering Cancer Center · USWeill Cornell Medicine · USKettering University · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Evolution and Changes in MetabolismP50CA086438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RIVIERI, ISABELLE · 2000 to 2015
$29.9M
MSK Paul Calabresi Career Development Award for Clinical OncologyK12CA184746 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Omar Abdel-Wahab, Simon N. Powell · 2015 to 2026
$8.3M
Novel PET imaging agents for understanding glutamine addiction in cancerR01CA164490 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHODOSH, LEWIS A, KUNG, HANK F · 2011 to 2015
$4.0M
Biomarkers for predicting response to Hsp90 therapyR01CA172546 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, DUNPHY, MARK P. · 2013 to 2017
$2.9M
First Human Trial of Src/Abl-Targeted PET Tumor Imaging with F-18 SKI-249380R21CA167803 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DUNPHY, MARK P. · 2012 to 2013
$736k
Auger Electron Radiotherapy of Late-Stage, Castration-Resistant Prostate Cancer using a Brominated Dihydrotestosterone AnalogueR21CA191913 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BEATTIE, BRADLEY J, VEACH, DARREN R · 2016 to 2017
$421k
Development of a Novel Peptide Platform for Targeted PET Imaging and Radiotherapy of Breast CancerF32EB025050 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI CARTER, LUKAS MICHAEL · 2017 to 2019
$179k
NCI NIH HHS K12 CA184746NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA086438NCI NIH HHS R01 CA164490NCI NIH HHS R01 CA172546NCI NIH HHS R21 CA167803NCI NIH HHS R21 CA191913NIBIB NIH HHS F32 EB025050
6 · The paper itself

Abstract

We developed a first-of-kind dasatinib-derivative imaging agent,

Indexed as

AgedDasatinibFemaleFluorine RadioisotopesHumansMaleMiddle AgedNeoplasmsPilot ProjectsPositron Emission Tomography Computed TomographyProspective StudiesProtein-Tyrosine KinasesRadiopharmaceuticalsWhole Body ImagingDasatinibFluorine RadioisotopesProtein-Tyrosine KinasesRadiopharmaceuticals18F-SKI-249380dasatinibPET imagingSrc kinase

Identifiers

PMID32169913
PMCPMC8524123
OpenAlexW3012239496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.