ArticleCurrent biology : CB2020
Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Contribution of spike timing to the neural code: from fast to slow timescales.Biological cybernetics · 2026Review
- Remodeling and Characterization Analysis of Corticospinal Tract in Patients with Intracerebral Hemorrhage in the Basal Ganglia.Translational stroke research · 2025Article
- Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex.Nature communications · 2025Article
- Cortico-cortical transfer of socially derived information gates emotion recognition.Nature neuroscience · 2024Article
- The tuning of tuning: How adaptation influences single cell information transfer.PLoS computational biology · 2024Article
- Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target.Science advances · 2024Article
- Article
- Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual evoked feedforward-feedback traveling waves organize neural activity across the cortical hierarchy in mice.Nature communications · 2022Article
- Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction.Neural regeneration research · 2022Article
- Translaminar recurrence from layer 5 suppresses superficial cortical layers.Nature communications · 2022Article
- Stimulus Feature-Specific Control of Layer 2/3 Subthreshold Whisker Responses by Layer 4 in the Mouse Primary Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging.Nature communications · 2022Article
- Complementary encoding of spatial information in hippocampal astrocytes.PLoS biology · 2022Article
- Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms.Frontiers in neural circuits · 2022Review
- A role for the cortex in sleep-wake regulation.Nature neuroscience · 2021Article
- Auditory input enhances somatosensory encoding and tactile goal-directed behavior.Nature communications · 2021Article
- Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins.eLife · 2021Article
- Prior expectations evoke stimulus-specific activity in the deep layers of the primary visual cortex.PLoS biology · 2020Article
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Authors and funding
12 authors.
Funding
Abstract
The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
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