ArticleNeuron2020
Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors.Neuron · 2026Article
- Thalamic reticular nucleus in the pathophysiology of schizophrenia.Neural regeneration research · 2026Article
- Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging.iScience · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Quantifying Structural Changes in Cultured Neurons Using Fractal Analysis.Neuroinformatics · 2026Article
- Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026Article
- Subcellular Structures in Native Hippocampal Synapses Revealed by Cryo-electron Tomography.Neuroscience bulletin · 2026Article
- Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy.Epilepsia · 2026Article
- Computing the effects of excitatory-inhibitory balance on neuronal input-output properties.PLoS computational biology · 2026Article
- Article
- Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence.Science advances · 2026Article
- Geometric principles of dendritic integration of excitation and inhibition in cortical neurons.Science advances · 2026Article
- Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data.Nature methods · 2025Article
- Increased NMDAR activity and GluN2A-NMDAR silent synapse expansion induced by chronic benzodiazepine treatment.Neuropharmacology · 2025Article
- Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain.Nature communications · 2025Article
- The CaInternational journal of molecular sciences · 2025Review
- A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines.Cell reports methods · 2025Article
- Amyloid β-dependent neuronal silencing through synaptic decoupling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstruction platform for mapping the size and spatial distribution of E and I synapses received by individual genetically-labeled layer 2/3 (L2/3) cortical pyramidal neurons (PNs) in vivo. We mapped over 90,000 E and I synapses across twelve L2/3 PNs and uncovered structured organization of E and I synapses across dendritic domains as well as within individual dendritic segments. Despite significant domain-specific variation in the absolute density of E and I synapses, their ratio is strikingly balanced locally across dendritic segments. Computational modeling indicates that this spatially precise E/I balance dampens dendritic voltage fluctuations and strongly impacts neuronal firing output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.