ArticleDevelopmental cell2020
Sperm Head-Tail Linkage Requires Restriction of Pericentriolar Material to the Proximal Centriole End.
Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- A MOPD II-associated Pericentrin variant disrupts PACT domain dimerization and pericentriolar material recruitment.bioRxiv : the preprint server for biology · 2026Article
- The Nuclear Pore Complex Facilitates Centriole-Nuclear Attachment in Spermatids.bioRxiv : the preprint server for biology · 2026Article
- Togaram Ensures Axial Alignment of the Sperm Neck.bioRxiv : the preprint server for biology · 2026Article
- Identification of a cytosol-to-nucleus feedback loop that regulates neuronal microtubule nucleation.The Journal of cell biology · 2026Article
- Transcriptome analyses reveal the fertility defect in the Dp(16)1Yey/+ mouse model of Down syndrome.Journal of assisted reproduction and genetics · 2026Article
- POC1A colocalizes with POC1B in human and bovine spermatozoa centrioles.microPublication biology · 2026Article
- Molecular models of the sperm head-tail coupling apparatus.Journal of cell science · 2025Review
- The PCM scaffold enables RNA localization to centrosomes.Molecular biology of the cell · 2025Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.G3 (Bethesda, Md.) · 2025Article
- Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice†.Biology of reproduction · 2025Article
- The proximal centriole-like structure maintains nucleus-centriole architecture in sperm.Journal of cell science · 2024Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.bioRxiv : the preprint server for biology · 2024Article
- Positioning centrioles and centrosomes.The Journal of cell biology · 2024Review
- The E3 ligase Poe promotes Pericentrin degradation.Molecular biology of the cell · 2023Article
- Nuclear elongation during spermiogenesis depends on physical linkage of nuclear pore complexes to bundled microtubules by Drosophila Mst27D.PLoS genetics · 2023Article
- Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development.eLife · 2023Article
- Pericentrin interacts with Kinesin-1 to drive centriole motility.The Journal of cell biology · 2022Article
- Orb-dependent polyadenylation contributes to PLP expression and centrosome scaffold assembly.Development (Cambridge, England) · 2022Article
- Multifaceted roles of centrosomes in development, health, and disease.Journal of molecular cell biology · 2021Review
- Microtubule Organizing Centers Contain Testis-Specific γ-TuRC Proteins in Spermatids of Drosophila.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The centriole, or basal body, is the center of attachment between the sperm head and tail. While the distal end of the centriole templates the cilia, the proximal end associates with the nucleus. Using Drosophila, we identify a centriole-centric mechanism that ensures proper proximal end docking to the nucleus. This mechanism relies on the restriction of pericentrin-like protein (PLP) and the pericentriolar material (PCM) to the proximal end of the centriole. PLP is restricted proximally by limiting its mRNA and protein to the earliest stages of centriole elongation. Ectopic positioning of PLP to more distal portions of the centriole is sufficient to redistribute PCM and microtubules along the entire centriole length. This results in erroneous, lateral centriole docking to the nucleus, leading to spermatid decapitation as a result of a failure to form a stable head-tail linkage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.