ArticleAntimicrobial resistance and infection control2020
The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa.
Article in Antimicrobial resistance and infection control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- In Vitro Activity of Mupirocin Against Methicillin-ResistantMicroorganisms · 2026Article
- Molecular characterization of mupirocin-resistant MRSA from Germany and South Africa.Frontiers in cellular and infection microbiology · 2026Article
- Synergistic Anti-Biofilm and Bactericidal Activity of Ethanol and Chlorhexidine Combined with EDTA AgainstInfection and drug resistance · 2026Article
- Clinical Features and Antibiotic Susceptibility ofJournal of clinical medicine · 2025Article
- Genomic Characterization and Safety Assessment ofJournal of microbiology and biotechnology · 2024Article
- Phenotypic and genotypic detection of multi drug resistant coagulase-positiveIranian journal of veterinary research · 2024Article
- Quality improvement study on the effectiveness of intranasal povidone-iodine decolonization on surgery patients.Infection prevention in practice · 2023Article
- TargetingFrontiers in oncology · 2023Article
- Article
- Mupirocin Promotes Wound Healing by Stimulating Growth Factor Production and Proliferation of Human Keratinocytes.Frontiers in pharmacology · 2022Article
- Microbial analysis and virulence genes detection of milk preserved using heat-assisted pulsed electric field.BMC research notes · 2021Article
- Article
- Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.Journal of clinical laboratory analysis · 2020Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial resistance is an increasingly serious problem in public health globally. Monitoring resistance levels within healthcare and community settings is critical to combat its ongoing increase. This study aimed to describe the rates and molecular mechanisms of mupirocin resistance in clinical Staphylococcus aureus isolates from Tygerberg Hospital, and to describe its association with strain types.
methodsWe retrospectively selected 212 S. aureus isolates which were identified from blood samples and pus swabs during the years 2009-2011 and 2015-2017. The isolates were identified using conventional microbiological methods and genotyping was done using spa typing. Cefoxitin (30 μg) disc diffusion and the two disc strategy (5 μg and 200 μg) were used to determine susceptibility to methicillin and mupirocin, respectively. Isolates with high-level resistance were screened for the plasmid mediated genes mupA and mupB by PCR, and sequencing of the ileS gene was done for all isolates exhibiting low-level resistance to describe the mutations associated with this phenotype. Chi-square test was used to assess the associations between mupirocin resistance and S. aureus genotypes.
resultsOf 212 S. aureus isolates, 12% (n = 25) were resistant to mupirocin, and 44% (n = 93) were methicillin resistant. Strain typing identified 73 spa types with spa t045 being the most predominant constituting 11% of the isolates. High-level mupirocin resistance was observed in 2% (n = 5), and low-level resistance in 9% (n = 20) of the isolates. The prevalence of high-level mupirocin resistance amongst MRSA and MSSA was 4 and 1% respectively, while the prevalence of low-level mupirocin resistance was significantly higher in MRSA (18%) compared to MSSA (3%), (p = 0.032). mupA was the only resistance determinant for high-level resistance, and the IleS mutation V588F was identified in 95% of the isolates which showed low-level resistance. A significant association was observed between spa type t032 and high-level mupirocin resistance, and types t037 and t012 and low-level resistance (p < 0.0001).
conclusionThe study reported higher rates of low-level mupirocin resistance compared to high-level resistance, and in our setting, mupirocin resistance was driven by certain genotypes. Our study advocates for the continuous screening for mupirocin resistance in S. aureus in clinical settings to better guide treatment and prescribing practices.
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