ArticleEnvironmental health : a global access science source2020
Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study.
Article in Environmental health : a global access science source, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- Emerging role of microplastics and nanoplastics in children's health.Pediatric research · 2026Review
- Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2025Article
- Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies.Journal of exposure science & environmental epidemiology · 2025Article
- Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health.Toxics · 2025Review
- Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.Toxics · 2025Article
- Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort.The Science of the total environment · 2024Article
- Maternal occupational exposure to asthmogenic during pregnancy and the future risk of asthma in children: A meta-analysis.Turkish journal of obstetrics and gynecology · 2024Article
- Recent Insights into the Environmental Determinants of Childhood Asthma.Current allergy and asthma reports · 2024Review
- Subpopulations of children with multiple chronic health outcomes in relation to chemical exposures in the ECHO-PATHWAYS consortium.Environment international · 2024Article
- Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cellsToxicology reports · 2023Article
- Prenatal phthalate exposure and early childhood wheeze in the SELMA study.Journal of exposure science & environmental epidemiology · 2022Article
- Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort.Frontiers in pharmacology · 2022Article
- Environmental Impacts on Infectious Disease: A Literature View of Epidemiological Evidence.Annals of global health · 2022Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPrenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years.
methodsFrom 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders.
results7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ΣDiNP
conclusionThe lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.