Evidence map›Paper›PMID 32168977›Full record

ReviewMicromachines2020

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review.

Kena Song, Guoqiang Li, Xiangyang Zu, Zhe Du, Liyu Liu, Zhigang Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Hypersound-Assisted Size Sorting of Microparticles on Inkjet-Patterned Protein Films.Langmuir : the ACS journal of surfaces and colloids · 2021
    Article
  14. Toward improvedAPL bioengineering · 2021
    Article
  15. Review
  16. Frontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kena SongCollege of Medical Technology and Engineering, Henan University of Science and Technology, He'nan 471023, China.
Guoqiang LiCollege of Physics, Chongqing University, Chongqing 401331, China.
Xiangyang ZuCollege of Medical Technology and Engineering, Henan University of Science and Technology, He'nan 471023, China.
Zhe DuCollege of Medical Technology and Engineering, Henan University of Science and Technology, He'nan 471023, China.
Liyu LiuCollege of Physics, Chongqing University, Chongqing 401331, China.
Zhigang HuCollege of Medical Technology and Engineering, Henan University of Science and Technology, He'nan 471023, China.

Funding

Scientific Research Foundation for the PhD (Henan University of Science and Technology) No. 13480030
6 · The paper itself

Abstract

Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.

Indexed as

extracellular matrix (ECM)materialmechanismmicrofluidicscaffoldstructure

Identifiers

PMID32168977
PMCPMC7143183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.