Evidence map›Paper›PMID 32168921›Full record

ArticleViruses2020

Study on the Antiviral Activities and Hemagglutinin-Based Molecular Mechanism of Novel Chlorogenin 3-

Wan-Zhen Shi, Ling-Zhi Jiang, Gao-Peng Song, Sheng Wang, Ping Xiong, Chang-Wen Ke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Wan-Zhen ShiDepartment of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510640, China.
Ling-Zhi JiangShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Gao-Peng SongDepartment of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510640, China.
Sheng WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Ping XiongDepartment of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510640, China.
Chang-Wen KeGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
South China Agricultural University · CNGuangdong Provincial Center for Disease Control and Prevention · CNHuazhong University of Science and Technology · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to investigate the inhibitory effect of chlorogenin 3-O-β-chacotrioside derivatives against H5N1 subtype of the highly pathogenic avian influenza (HPAI) viruses and its molecular mechanism. A series of novel small molecule pentacyclic triterpene derivatives were designed and synthesized and their antiviral activities on HPAI H5N1 viruses were detected. The results displayed that the derivatives UA-Nu-ph-5, XC-27-1 and XC-27-2 strongly inhibited wild-type A/Duck/Guangdong/212/2004 H5N1 viruses with the IC

Indexed as

AnimalsAntiviral AgentsBinding SitesCell LineCell SurvivalChick EmbryoDose-Response Relationship, DrugEnzyme ActivationHemagglutination Inhibition TestsHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N1 SubtypeModels, MolecularMolecular ConformationMolecular StructureNeutralization TestsAntiviral AgentsHemagglutinin Glycoproteins, Influenza Virusantiviral mechanismchlorogenin 3-O-β-chacotrioside derivativesH5N1 subtype avian influenza virushemagglutinin

Identifiers

PMID32168921
PMCPMC7150989
OpenAlexW3012081449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.