Evidence map›Paper›PMID 32168858›Full record

ArticleMolecules (Basel, Switzerland)2020

BEL β-Trefoil Reduces the Migration Ability of RUNX2 Expressing Melanoma Cells in Xenotransplanted Zebrafish.

Maria Teresa Valenti, Giulia Marchetto, Massimiliano Perduca, Natascia Tiso, Monica Mottes, Luca Dalle Carbonare

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maria Teresa ValentiDepartment of Medicine, University of Verona, University of Verona, Ple Scuro, 10, 37100 Verona, Italy.ORCID 0000-0003-1166-8033
Giulia MarchettoDepartment of Medicine, University of Verona, University of Verona, Ple Scuro, 10, 37100 Verona, Italy.
Massimiliano PerducaDepartment of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.ORCID 0000-0001-8291-0523
Natascia TisoDepartment of Biology, University of Padova, I-35131 Padova, Italy.ORCID 0000-0002-5444-9853
Monica MottesDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 10, 37100 Verona, Italy.ORCID 0000-0002-7390-2246
Luca Dalle CarbonareDepartment of Medicine, University of Verona, University of Verona, Ple Scuro, 10, 37100 Verona, Italy.ORCID 0000-0003-3263-6671
University of Verona · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RUNX2, a master osteogenic transcript ion factor, is overexpressed in several cancer cells; in melanoma it promotes cells migration and invasion as well as neoangiogenesis. The annual mortality rates related to metastatic melanoma are high and novel agents are needed to improve melanoma patients' survival. It has been shown that lectins specifically target malignant cells since they present the Thomsen-Friedenreich antigen. This disaccharide is hidden in normal cells, while it allows selective lectins binding in transformed cells. Recently, an edible lectin named BEL β-trefoil has been obtained from the wild mushroom

Indexed as

AnimalsAntineoplastic AgentsBasidiomycotaCell Line, TumorCell MovementCell ProliferationCloning, MolecularCore Binding Factor Alpha 1 SubunitEmbryo, NonmammalianEscherichia coliFungal ProteinsGene ExpressionGenetic VectorsHumansMelanocytesMelanomaAntineoplastic AgentsCore Binding Factor Alpha 1 SubunitFungal ProteinsRecombinant Fusion ProteinsRUNX2 protein, humanTrefoil FactorsBEL β-trefoillectinmelanomaRUNX2zebrafish

Identifiers

PMID32168858
PMCPMC7143993
OpenAlexW3012515482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.