ReviewNutrients2020
Beyond Heat Stress: Intestinal Integrity Disruption and Mechanism-Based Intervention Strategies.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Comparative efficacy of portable active cooling vs. passive cooling for reducing core temperature in exertional heat stroke: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Occupational heatstroke-induced acute kidney injury: a narrative review of mechanisms, biomarkers, and the timing of blood purification initiation.Renal failure · 2026Review
- The effect of increasing dietary Vitamin E and D doses on the performance of broilers andVeterinary and animal science · 2026Article
- Climate Change and Food Allergy: Adaptations and Risks at the Intersection of Environment and Health.Comprehensive reviews in food science and food safety · 2026Review
- Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses.Microbiome · 2026Article
- Tissue-specific oxidative responses and recovery following acute thermal stress in juvenile Amazonian fish Colossoma macropomum.Fish physiology and biochemistry · 2026Article
- Article
- Heat stress and corn quality affect amino acid digestibility in broiler chickens.Poultry science · 2026Article
- Probiotic Bifidobacterium Confers Protection Against Heat Stroke Through Enhancement of Intestinal Barrier Function in Rats.Shock (Augusta, Ga.) · 2026Article
- Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species-An In Silico Supported Review.Food science & nutrition · 2026Review
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- Stochasticity Prevails but Differs: Tissue-Specific Assembly of Gut Microbiomes Across Seasons in an Amphibian Model.Ecology and evolution · 2026Article
- Dietary Sheep Blood Zymolysate Modulates Gut Barrier Integrity, Microbiota Composition, and Nutritional Metabolism in Common Carp (Aquaculture nutrition · 2026Article
- Heat stress-induced gut dysbiosis and multi-organ injury: mechanisms and therapeutic modulation.Frontiers in cellular and infection microbiology · 2026Review
- Ambient temperature, rainfall, and adverse maternal and child health outcomes in Nigeria: evidence from a national cross-sectional study.Frontiers in public health · 2026Article
- Comparative effects of β-glucan and mannan oligosaccharides on heat stress-induced inflammation: associations with gut barrier integrity and intestinal microbiota in mice.Frontiers in nutrition · 2026Article
- Gut microbiota modulation in the prevention and treatment of heat stroke.Frontiers in immunology · 2026Review
- Exercise-induced intestinal barrier dysfunction: a potential contributor to athlete mental health.BMJ open sport & exercise medicine · 2026Article
- A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment.Journal of inflammation research · 2026Review
- Dietary Chlorogenic Acid Supplementation Alleviates Heat Stress-Induced Intestinal Oxidative Damage by Activating Nrf2 Signaling in Rabbits.Antioxidants (Basel, Switzerland) · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current climate changes have increased the prevalence and intensity of heat stress (HS) conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial barrier integrity due to hyperthermia and hypoxia following blood repartition, which often results in a leaky gut followed by penetration and transfer of luminal antigens, endotoxins, and pathogenic bacteria. Under extreme conditions, HS may culminate in the onset of "heat stroke", a potential lethal condition if remaining untreated. HS-induced alterations of the gastrointestinal epithelium, which is associated with a leaky gut, are due to cellular oxidative stress, disruption of intestinal integrity, and increased production of pro-inflammatory cytokines. This review summarizes the possible resilience mechanisms based on in vitro and in vivo data and the potential interventions with a group of nutritional supplements, which may increase the resilience to HS-induced intestinal integrity disruption and maintain intestinal homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.