Evidence map›Paper›PMID 32168391›Full record

ArticlePacing and clinical electrophysiology : PACE2020

Fetal diagnosis of KCNQ1-variant long QT syndrome using fetal echocardiography and magnetocardiography.

Lajja Desai, Ron Wakai, Sabrina Tsao, Janette Strasburger, Nina Gotteiner, Angira Patel

Open access · greenAbstract readCase Reports
In one paragraph

Article in Pacing and clinical electrophysiology : PACE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. The magnetocardiogram.Biophysics reviews · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Lajja DesaiAnn and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-1647-1283
Ron WakaiDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Sabrina TsaoQueen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.
Janette StrasburgerChildren's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.
Nina GotteinerAnn and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Angira PatelAnn and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Northwestern University · USChildren's Hospital of Wisconsin · USQueen Mary Hospital · CNUniversity of Wisconsin–Madison · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Optimized Signal Processing of Fetal MCG R01HL063174 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WAKAI, RONALD T · 1999 to 2020
$8.4M
Northwestern University Clinical and Translational Science Institute (NUCATS)TL1TR001423 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCCOLLEY, SUSANNA A · 2015 to 2023
$5.0M
NCATS NIH HHS TL1 TR001423NCATS NIH HHS TL1TR001423NCATS NIH HHS UL1 TR001422NHLBI NIH HHS R01 HL063174NIH HHS R01HL063174
6 · The paper itself

Abstract

A pregnant woman with KCNQ1 variant long QT syndrome (LQTS) underwent fetal magnetocardiography (fMCG) after atrioventricular (AV) block was noted during fetal echocardiogram-atypical for LQTS type 1. Concern for fetal LQTS on fMCG prompted monitoring of maternal labs, change of maternal beta blocker therapy, and frequent fetal echocardiograms. Collaboration between obstetricians, neonatologists, and pediatric cardiologists ensured safe delivery. Beta blocker therapy was initiated after birth, and postnatal evaluation confirmed genotype and phenotype positive LQTS in the infant. Our experience suggests diagnosis and evaluation of fetal LQTS can alter antenatal management to reduce risk of poor fetal and postnatal outcomes.

Indexed as

EchocardiographyMagnetocardiographyAdultFemaleHumansKCNQ1 Potassium ChannelLong QT SyndromePregnancyPrenatal DiagnosisKCNQ1 Potassium ChannelKCNQ1 protein, humanfetal bradycardiafetal echocardiographyfetal magnetocardiographylong QT syndrome

Identifiers

PMID32168391
PMCPMC7166171
OpenAlexW3012158834

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.