SynthesisPLoS neglected tropical diseases2020
The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Non-genetic risk factors of miscarriage: a comprehensive umbrella review of systematic review and meta-analysis.Reproductive health · 2025Pooled it
- Toxoplasmosis landscape: a systematic review and meta-analysis of seroprevalence in healthy and non-healthy individuals in Sudan (1990-2025).BMC infectious diseases · 2025Pooled it
- Seroprevalence of anti-ToxoplasmaIgG among the human population in Indonesia: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Toxoplasma gondii seroprevalence among pregnant women in Africa: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Potential risk factors associated with seropositivity for Toxoplasma gondii among pregnant women and HIV infected individuals in Ethiopia: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- Seroprevalence and molecular detection ofFood and waterborne parasitology · 2026Article
- Molecular Identification ofJournal of parasitology research · 2026Article
- Unraveling the link: serological and molecular insights into Toxoplasma gondii infection in women with spontaneous abortion history.Tropical diseases, travel medicine and vaccines · 2025Article
- Toxoplasma gondii C2 Domain Protein Deletion Mutant as a Promising Vaccine Against Toxoplasmosis in Mice.Microbial biotechnology · 2025Article
- Seroprevalence and molecular detection of Toxoplasma gondii and Neospora caninum in beef cattle and goats in Hunan province, China.Parasites & vectors · 2024Article
- Toxoplasma gondii modulates the host cell cycle, chromosome segregation, and cytokinesis irrespective of cell type or species origin.Parasites & vectors · 2024Article
- Anti-Toxoplasma gondii effect of tylosin in vitro and in vivo.Parasites & vectors · 2024Article
- Identification of novel biomarkers for anti-Frontiers in microbiology · 2024Article
- Boosting Mouse Defense against LethalVaccines · 2023Article
- Seroprevalence, Risk Factors and Maternal-Fetal Outcomes ofPathogens (Basel, Switzerland) · 2023Review
- Tryptophan metabolism and immune alterations in pregnant Hispanic women with chronic Toxoplasma gondii infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Gestational toxoplasmosis treatment changes the child's prognosis: A cohort study in southern Brazil.PLoS neglected tropical diseases · 2023Article
- A large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran.Folia parasitologica · 2023Article
- Modeling the human placental barrier to understandFrontiers in cellular and infection microbiology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasma gondii (T. gondii) is an intracellular pathogen that can lead to abortion in pregnant women infected with this parasite. Therefore, the present study aimed to estimate the global seroprevalence of anti-T. gondii antibodies in women who had spontaneous abortion based on the results of published articles and evaluate the relationship between seroprevalence of anti-T. gondii antibodies and abortion via a systematical review and meta-analysis.
methodsDifferent databases were searched in order to gain access to all studies on the seroprevalence of anti- T. gondii antibodies in women who had spontaneous abortion and association between seroprevalence of anti-T. gondii antibodies and abortion published up to April 25th, 2019. Odds ratio (OR) and the pooled rate seroprevalence of T. gondii with a 95% confidence interval (CI) were calculated using the random effects model.
resultsIn total, 8 cross-sectional studies conducted on 1275 women who had abortion in present pregnancy, 40 cross-sectional studies performed on 9122 women who had a history of abortion, and 60 articles (involving 35 cross-sectional studies including 4436 women who had spontaneous abortion as case and 10398 as control and 25 case-control studies entailing 4656 cases and 3178 controls) were included for the final analyses. The random-effects estimates of the prevalence of anti-T. gondii IgG antibody in women who had abortion in present pregnancy and women who had a history of abortion were 33% (95% CI: 17%-49%) and 43% (95% CI: 27%-60%), respectively. In addition, the pooled OR for anti-T. gondii IgG antibody in cross-sectional and case-control studies among women who had spontaneous abortion were 1.65 (95% CI: 1.31-2.09) and 2.26 (95% CI: 1.56-3.28), respectively. Also, statistical analysis showed that the pooled OR of the risk of anti-T. gondii IgM antibody 1.39 (95% CI: 0.61-3.15) in cross-sectional and 4.33 (95% CI: 2.42-7.76) in case-control studies.
conclusionBased on the results of the current study, T. gondii infection could be considered a potential risk factor for abortion. It is recommended to carry out further and more comprehensive investigations to determine the effect of T. gondii infection on abortion to prevent and control toxoplasmosis among pregnant women around the world.
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