SynthesisPloS one2020
The links between supplementary tannin levels and conjugated linoleic acid (CLA) formation in ruminants: A systematic review and meta-analysis.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Quebranta grape pomace from the Ica Valley improves milk lipid profile in Saanen goats.Open veterinary journal · 2026Article
- Biotechnology Approaches to Dairy Alternatives Through Precision Fermentation and Cellular Agriculture.Food science of animal resources · 2025Review
- Meta-Analysis of Dietary Interventions for Enteric Methane Mitigation in Ruminants Through Methodological Advancements and Implementation Pathways.Veterinary sciences · 2025Article
- Meta-Analysis of Dietary Tannins in Small Ruminant Diets: Effects on Growth Performance, Serum Metabolites, Antioxidant Status, Ruminal Fermentation, Meat Quality, and Fatty Acid Profile.Animals : an open access journal from MDPI · 2025Article
- Impact of rearing systems in the Eastern Amazon on cholesterol, β-carotene and vitamin E homologues in steer.Frontiers in veterinary science · 2024Article
- The Effect of Neem Leaf Supplementation on Growth Performance, Rumen Fermentation, and Ruminal Microbial Population in Goats.Animals : an open access journal from MDPI · 2023Article
- Effects of Sulla Flexuosa Hay as Alternative Feed Resource on Goat's Milk Production and Quality.Animals : an open access journal from MDPI · 2023Article
- A Short-Term Supplementation with a Polyphenol-Rich Extract from Radiata Pine Bark Improves Fatty Acid Profiles in Finishing Lambs.Animals : an open access journal from MDPI · 2023Article
- Lambs supplemented with Amazonian oilseed co-products: Meat quality and fatty acid profile.PloS one · 2023Article
- Sustainable Valorization of Tomato Pomace (Animals : an open access journal from MDPI · 2022Review
- Effect of Purple Neem Foliage as a Feed Supplement on Nutrient Apparent Digestibility, Nitrogen Utilization, Rumen Fermentation, Microbial Population, Plasma Antioxidants, Meat Quality and Fatty Acid Profile of Goats.Animals : an open access journal from MDPI · 2022Article
- Nutritional Composition of Black Soldier Fly Larvae (Insects · 2022Review
- Modulatory effects of dietary tannins on polyunsaturated fatty acid biohydrogenation in the rumen: A meta-analysis.Heliyon · 2022Article
- Empirical Evaluation and Prediction of Protein Requirements for Maintenance and Growth of 18-24 Months Old Thai Swamp Buffaloes.Animals : an open access journal from MDPI · 2021Article
- Effects of Increasing Doses of Condensed Tannins Extract fromAnimals : an open access journal from MDPI · 2021Article
- Effect of Supplementation With Selenium-Yeast on Muscle Antioxidant Activity, Meat Quality, Fatty Acids and Amino Acids in Goats.Frontiers in veterinary science · 2021Article
- Black Wattle (Animals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A systematic review and meta-analysis were conducted to predict and identify ways to increase conjugated linoleic acid (CLA) formation in ruminant-derived products to treat human health issues with dietary tannins. The objective was to compare and confirm the effects of dietary tannins on CLA formation by analyzing in vitro and/or in vivo studies. We reported the results of the meta-analysis based on numerical data from 38 selected publications consisting of 3712 treatments. Generally, via multiple pathways, the CLA formation increased when dietary tannins increased. Concurrently, dietary tannins increased Δ9 desaturation and the CLA indices in milk and meat (P < 0.05 and P < 0.001, with average R2 values of 0.23 and 0.44, respectively), but they did not change the rumen fermentation characteristics, including total volatile fatty acids (mmol/L) and their acid components. In vitro observations may accurately predict in vivo results. Unfortunately, there was no relationship between in vitro observations and in vivo results (R2 < 0.10), indicating that it is difficult to predict CLA formation in vivo considering in vitro observations. According to the statistical meta-analysis results regarding animal aspects, the ranges of tannin levels required for CLA formation in vitro and in vivo were approximately 0.1-20 g/kg dry matter (DM) (P < 0.001) and 2.1-80 g/kg DM (P < 0.001), respectively. In conclusion, the in vivo method was more suitable for the direct observation of fatty acid transformation than the in vitro method.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.