Evidence map›Paper›PMID 32168327›Full record

ArticlePLoS genetics2020

A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuage.

Zsolt G Venkei, Charlotte P Choi, Suhua Feng, Cuie Chen, Steven E Jacobsen, John K Kim, Yukiko M Yamashita

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zsolt G VenkeiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.
Charlotte P ChoiDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America.ORCID 0000-0002-1857-6599
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States of America.
Cuie ChenLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.ORCID 0000-0002-5498-9753
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States of America.ORCID 0000-0001-9483-138X
John K KimDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America.
Yukiko M YamashitaLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.ORCID 0000-0001-5541-0216
Howard Hughes Medical Institute · USJohns Hopkins University · USUniversity of Michigan · USUniversity of California, Los Angeles · US

Funding

The role of post-translational modifications in miRISC functionR01GM118875 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KIM, JOHN · 2016 to 2019
$1.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM118875
6 · The paper itself

Abstract

The piRNA pathway protects germline genomes from selfish genetic elements (e.g. transposons) through their transcript cleavage in the cytoplasm and/or their transcriptional silencing in the nucleus. Here, we describe a mechanism by which the nuclear and cytoplasmic arms of the piRNA pathway are linked. We find that during mitosis of Drosophila spermatogonia, nuclear Piwi interacts with nuage, the compartment that mediates the cytoplasmic arm of the piRNA pathway. At the end of mitosis, Piwi leaves nuage to return to the nucleus. Dissociation of Piwi from nuage occurs at the depolymerizing microtubules of the central spindle, mediated by a microtubule-depolymerizing kinesin, Klp10A. Depletion of klp10A delays the return of Piwi to the nucleus and affects piRNA production, suggesting the role of nuclear-cytoplasmic communication in piRNA biogenesis. We propose that cell cycle-dependent communication between the nuclear and cytoplasmic arms of the piRNA pathway may play a previously unappreciated role in piRNA regulation.

Indexed as

AnimalsArgonaute ProteinsCell CycleCell Cycle ProteinsCell DivisionCell NucleusCytoplasmDNA Transposable ElementsDrosophila melanogasterDrosophila ProteinsFemaleGene SilencingGerm CellsKinesinsMaleOvaryArgonaute ProteinsCell Cycle ProteinsDNA Transposable ElementsDrosophila ProteinsKinesinsKLP10A protein, Drosophilapiwi protein, DrosophilaRNA, Small Interfering

Identifiers

PMID32168327
PMCPMC7094869
OpenAlexW3011190051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.