Evidence map›Paper›PMID 32168057›Full record

ArticleClinical orthopaedics and related research2020

Projections of Primary TKA and THA in Germany From 2016 Through 2040.

Markus Rupp, Edmund Lau, Steven M Kurtz, Volker Alt

3 registry-linked trialsAbstract read
In one paragraph

Article in Clinical orthopaedics and related research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 129 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05563155 phase4completednot on this mapstarted 2021, after this paper: background citation

Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response - A Randomized Double-blind Placebo-controlled Trial

TypeinterventionalSponsorVejle HospitalRan2021 to 2024Enrolled110ConditionsPost Operative Pain, AcuteArmsDexamethasone 24 mg, Placebo
NCT06088602 naunknown statusnot on this mapstarted 2024, after this paper: background citation

The Effect of Cryoneurolysis for the Treatment of Acute Postoperative Pain Following Total Knee Arthroplasty in High Pain Responders - A Randomized, Participant- and Observer-masked, Sham-controlled Trial

TypeinterventionalSponsorCopenhagen University Hospital, HvidovreRan2024 to 2025Enrolled44ConditionsAcute Postoperative PainArmsCryoneurolysis, Sham
NCT06292663 nacompletednot on this mapstarted 2024, after this paper: background citation

Can Preoperative Information Via Virtual Reality Affect Patient's Anxiety? A Randomized Controlled Trial and Patient Interviews

TypeinterventionalSponsorZealand University HospitalRan2024 to 2025Enrolled88ConditionsAnxiety, Surgery, PainArmsVirtual Reality
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  6. Novel diagnostic markers for periprosthetic joint infection: a systematic review.Frontiers in cellular and infection microbiology · 2023
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Markus RuppM. Rupp, V. Alt, Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany.
Edmund LauE. Lau, Exponent Inc, Menlo Park, CA, USA.
Steven M KurtzS. M. Kurtz, Exponent Inc, Philadelphia, PA, USA.
Volker AltM. Rupp, V. Alt, Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany.

Funding

Comparing hospitalization rates, outcomes, and treatment intensity for elderly patients across OECD countriesR01AG058878 · NIA · HARVARD MEDICAL SCHOOL · PI Peter M Cram, Bruce E. Landon · 2019 to 2026
$3.4M
NIA NIH HHS R01 AG058878
6 · The paper itself

Abstract

backgroundFuture projections for both TKA and THA in the United States and other countries forecast a further increase of already high numbers of joint replacements. The consensus is that in industrialized countries, this increase is driven by demographic changes with more elderly people being less willing to accept activity limitations. Unlike the United States, Germany and many other countries face a population decline driven by low fertility rates, longer life expectancy, and immigration rates that cannot compensate for population aging. Many developing countries are likely to follow that example in the short or medium term amid global aging. Due to growing healthcare expenditures in a declining and aging population with a smaller available work force, reliable predictions of procedure volume by age groups are requisite for health and fiscal policy makers to maintain high standards in arthroplasty for the future population.Questions/purposes (1) By how much is the usage of primary TKA and THA in Germany expected to increase from 2016 through 2040? (2) How is arthroplasty usage in Germany expected to vary as a function of patient age during this time span?

methodsThe annual number of primary TKAs and THAs were calculated based on population projections and estimates of future healthcare expenditures as a percent of the gross domestic product (GDP) in Germany. For this purpose, a Poisson regression analysis using age, gender, state, healthcare expenditure, and calendar year as covariates was performed. The dependent variable was the historical number of primary TKAs and THAs performed as compiled by the German federal office of statistics for the years 2005 through 2016.

resultsThrough 2040, the incidence rate for both TKA and THA will continue to increase annually. For TKA, the incidence rate is expected to increase from 245 TKAs per 100,000 inhabitants to 379 (297-484) (55%, 95% CI 21 to 98). The incidence rate of THAs is anticipated to increase from 338 to 437 (357-535) per 100,000 inhabitants (29% [95% CI 6 to 58]) between 2016 and 2040. The total number of TKAs is expected to increase by 45% (95% CI 14 to 8), from 168,772 procedures in 2016 to 244,714 (95% CI 191,920 to 312,551) in 2040. During the same period, the number of primary THAs is expected to increase by 23% (95% CI 0 to 50), from 229,726 to 282,034 (95% CI 230,473 to 345,228). Through 2040, the greatest increase in TKAs is predicted to occur in patients aged 40 to 69 years (40- to 49-year-old patients: 269% (95% CI 179 to 390); 50- to 59-year-old patients: 94% (95% CI 48 to 141); 60- to 69-year-old patients: 43% (95% CI 13 to 82). The largest increase in THAs is expected in the elderly (80- to 89-year-old patients (71% [95% CI 40 to 110]).

conclusionsAlthough the total number of TKAs and THAs is projected to increase in Germany between now and 2040, the increase will be smaller than that previously forecast for the United States, due in large part to the German population decreasing over that time, while the American population increases. Much of the projected increase in Germany will be from the use of TKA in younger patients and from the use of THA in elderly patients. Knowledge of these trends may help planning by surgeons, hospitals, stakeholders, and policy makers in countries similar to Germany, where high incidence rates of arthroplasty, aging populations, and overall decreasing populations are present. LEVEL OF EVIDENCE: Level III, economic and decision analysis.

Indexed as

AdultAgedAged, 80 and overAge DistributionAgingArthroplasty, Replacement, HipArthroplasty, Replacement, KneeFemaleForecastingGermanyGross Domestic ProductHealth Care CostsHealth ExpendituresHealth Services Needs and DemandHumansLife Expectancy

Identifiers

PMID32168057
PMCPMC7310374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.