ArticleEpidemiology (Cambridge, Mass.)2020
Residential Proximity to Intensive Animal Agriculture and Risk of Lymphohematopoietic Cancers in the Agricultural Health Study.
Article in Epidemiology (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A systematic review of animal feeding operations including concentrated animal feeding operations (CAFOs) for exposure, health outcomes, and environmental justice.Environmental research · 2024Pooled it
- Residential proximity to intensive animal agriculture associates with increased prevalence of antimicrobial resistance in homes.Journal of exposure science & environmental epidemiology · 2026Article
- Density of animal feeding operations, including concentrated animal feeding operations (CAFOs), and cancer incidence: A county-level ecological study across three U.S. states.Environmental research · 2026Article
- Disparities in exposure to concentrated animal feeding operations (CAFOs) and other animal feeding operations across multiple states in USA.Journal of exposure science & environmental epidemiology · 2026Article
- Health disparities associated with exposure to animal feeding operations, including concentrated animal feeding operations (CAFOs), in North Carolina, Pennsylvania, and Virginia, USA.Environmental research letters : ERL [Web site] · 2025Article
- Article
- Concentrated animal feeding operations (CAFOs) in relation to environmental justice related variables in Wisconsin, United States.Journal of exposure science & environmental epidemiology · 2024Article
- Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes.Nature microbiology · 2024Article
- Review
- Distribution of environmental justice metrics for exposure to CAFOs in North Carolina, USA.Environmental research · 2021Article
- sparrpowR: a flexible R package to estimate statistical power to identify spatial clustering of two groups and its application.International journal of health geographics · 2021Article
- Spatial Heterogeneity in Positional Errors: A Comparison of Two Residential Geocoding Efforts in the Agricultural Health Study.International journal of environmental research and public health · 2021Article
- Residential proximity to agriculture and risk of childhood leukemia and central nervous system tumors in the Danish national birth cohort.Environment international · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough occupational exposure to animals has been associated with lymphohematopoietic malignancies, to our knowledge no studies have evaluated adult cancer risks associated with living near intensive animal agriculture.
methodsWe linked participants in the prospective Agricultural Health Study to permitted animal feeding operations in Iowa. We created metrics reflecting the intensity of animal exposures within 2 and 5 km of participants' residences, enumerating both total and inverse distance-weighted animal units (AUs), standardized by animal size and manure production. We estimated risk of lymphohematopoietic malignancies and subtypes [hazard ratio (HR), 95% confidence interval (95% CI)], adjusting for demographic and farming-related factors, including occupational pesticide exposure. We stratified associations by animal type and animal-related work activities.
resultsWe observed 519 cases (1993-2015) among 32,635 pesticide applicators and 211 cases among 19,743 spouses. Among applicators, no associations were evident within 2 km, but risk of any lymphohematopoietic cancer was elevated across quintiles of weighted AUs within 5 km. Risk of non-Hodgkin lymphoma (NHL) was elevated for the second (HR = 1.5; 95% CI, 1.1, 2.1), third (HR = 1.6; 95% CI, 1.1, 2.2), and fourth (HR = 1.7; 95% CI, 1.3, 2.4) highest quintiles of weighted AUs within 5 km (Ptrend = 0.52) and increased with dairy cattle AUs (Ptrend = 0.04). We found positive trends for leukemia and some NHL subtypes with increasing numbers of both beef and dairy cattle. Risks did not vary by animal-related work (Pinteraction = 0.61). Associations were similar using the total exposure metric and inconsistent among spouses.
conclusionResidential proximity to intensive animal agriculture was positively associated with risk of NHL and leukemia, even after consideration of occupational animal and pesticide exposures.
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