ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020
Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Validation of Invasive Area for Predicting Sentinel Node Status and Survival in Primary Cutaneous Melanoma.Annals of surgical oncology · 2025Article
- Article
- Predicting cardiac resynchronization therapy response: development and validation of a single photon emission computed tomography-based nomogram.Quantitative imaging in medicine and surgery · 2025Article
- TPM4 influences the initiation and progression of gastric cancer by modulating ferroptosis via SCD1.Clinical and experimental medicine · 2025Article
- Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Using Nomograms Wisely: Predicting Sentinel Node Positivity in Melanoma.Annals of surgical oncology · 2024Article
- Nomogram-based prognostic stratification for patients with large hepatocellular carcinoma: a population study of SEER database and a Chinese cohort.Journal of gastrointestinal oncology · 2024Article
- Impact of an Online Risk Calculator for Sentinel Node Positivity on Management of Patients with T1 and T2 Melanomas.Annals of surgical oncology · 2024Article
- The Burden of Thin Melanomas in Tuscany, Italy, 1985-2017: Age- and Sex-Specific Temporal Trends in Incidence and Mortality.Cancers · 2024Article
- Service implications of the revised 2022 National Institute for Health and Care Excellence (NICE) follow-up guidelines for stage IA-IIC melanoma.The British journal of surgery · 2024Article
- Prognostic analysis of cutaneous Kaposi sarcoma based on a competing risk model.Scientific reports · 2023Article
- The Role of Clinicopathologic Nomograms for Melanoma in the Era of Gene Expression Profiling.Annals of surgical oncology · 2023Article
- The Impact of Clinical and Histopathological Factors on Disease Progression and Survival in Thick Cutaneous Melanomas.Biomedicines · 2023Article
- A Clinical Decision Tool to Calculate Pretest Probability of Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.Annals of surgical oncology · 2023Article
- Development and validation of a risk prediction model for cage subsidence after instrumented posterior lumbar fusion based on machine learning: a retrospective observational cohort study.Frontiers in medicine · 2023Article
- Prognostic nomogram and novel risk-scoring system for small cell lung cancer with different patterns of metastases.General thoracic and cardiovascular surgery · 2022Article
- Sentinel Lymph Node Biopsy in Cutaneous Melanoma, a Clinical Point of View.Medicina (Kaunas, Lithuania) · 2022Review
- Predictors of Sentinel Lymph Node Metastasis in Patients with Thin Melanoma: An International Multi-institutional Collaboration.Annals of surgical oncology · 2022Article
- Early Diagnosis of Bipolar Disorder Coming Soon: Application of an Oxidative Stress Injury Biomarker (BIOS) Model.Neuroscience bulletin · 2022Article
- Dermoscopy for Cutaneous Melanoma: Under the Eye of Both the Dermatologist and the Legal Doctor.Dermatology practical & conceptual · 2022Review
Corrections and comments
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- Erratum issuedErrata.2020
Authors and funding
48 authors at 20 institutions in 13 countries.
Funding
Abstract
purposeThin melanomas (T1; ≤ 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma guidelines do not provide clear indications on when to perform SNB in T1 disease and stress an individualized approach to SNB that considers all clinicopathologic risk factors. We aimed to identify determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better select patients with T1 disease for SNB. PATIENTS AND
methodsThe development cohort comprised 3,666 patients with T1 disease consecutively treated at the Istituto Nazionale Tumori (Milan, Italy) between 2001 and 2018; 4,227 patients with T1 disease treated at 13 other European centers over the same period formed the validation cohort. A random forest procedure was applied to the development data set to select characteristics associated with SN status for inclusion in a multiple binary logistic model from which a nomogram was elaborated. Decision curve analyses assessed the clinical utility of the nomogram.
resultsOf patients in the development cohort, 1,635 underwent SNB; 108 patients (6.6%) were SN positive. By univariable analysis, age, growth phase, Breslow thickness, ulceration, mitotic rate, regression, and lymphovascular invasion were significantly associated with SN status. The random forest procedure selected 6 variables (not growth phase) for inclusion in the logistic model and nomogram. The nomogram proved well calibrated and had good discriminative ability in both cohorts. Decision curve analyses revealed the superior net benefit of the nomogram compared with each individual variable included in it as well as with variables suggested by current guidelines.
conclusionWe propose the nomogram as a decision aid in all patients with T1 melanoma being considered for SNB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.