Evidence map›Paper›PMID 32167780›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Tumor necrosis factor-α impairs cerebral blood flow in pregnant rats: role of vascular β-epithelial Na

Jeremy W Duncan, Subhi Talal Younes, Emily Hildebrandt, Michael J Ryan, Joey P Granger, Heather A Drummond

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeremy W DuncanDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-8884-3018
Subhi Talal YounesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0003-4320-0355
Emily HildebrandtDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Michael J RyanDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-5679-6031
Joey P GrangerDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Heather A DrummondDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jackson Memorial Hospital · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI JONES, ALAN E · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Placental Ischemia, Hypertension and HemodyanmicsR01HL136684 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI DRUMMOND, HEATHER A, GRANGER, JOEY P. · 2017 to 2020
$1.7M
NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL136684NHLBI NIH HHS T32 HL105324NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Preeclampsia is a pregnancy-related disorder characterized by hypertension, vascular dysfunction and an increase in circulating inflammatory factors including the cytokine, tumor necrosis factor-α (TNF-α). Studies have shown that placental ischemia is associated with

Indexed as

Cerebrovascular CirculationAnimalsBlood PressureCell LineCells, CulturedCerebral ArteriesEpithelial Sodium ChannelsFemaleHomeostasisMAP Kinase Signaling SystemMuscle, Smooth, VascularPre-EclampsiaPregnancyProtein Kinase InhibitorsRatsRats, Sprague-DawleyEpithelial Sodium ChannelsProtein Kinase InhibitorsTumor Necrosis Factor-alphacerebral blood flowJNKp38MAPKTNF-αvascular smooth muscle cellsβENaC

Identifiers

PMID32167780
PMCPMC7191490
OpenAlexW3011194720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.