Evidence map›Paper›PMID 32167620›Full record

ArticleNephrology (Carlton, Vic.)2020

Serum electrolyte dynamics in multiple myeloma patients undergoing autologous haematopoietic stem cell transplantation.

Apoorva Anandan, Merle Kolk, Nicole Ferrari, Melissa Copley, James Driscoll, Paolo Caimi, Arash Rashidi, Marcos de Lima, Ehsan Malek

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology (Carlton, Vic.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Apoorva AnandanInternal Medicine Department, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Merle KolkAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Nicole FerrariAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Melissa CopleyAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
James DriscollDivision of Hematology & Oncology, University of Cincinnati, Cincinnati, Ohio, USA.
Paolo CaimiAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Arash RashidiNephrology division, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Marcos de LimaAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Ehsan MalekAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-4719-4327
University Hospitals Seidman Cancer Center · USUniversity Hospitals of Cleveland · USUniversity of Cincinnati · US

Funding

TARGETING HUMAN PLASMA CELLS TO OVERCOME HUMORAL RESPONSES IN TRANSPLANTATIONR01AI139141 · NIAID · UNIVERSITY OF CINCINNATI · PI DRISCOLL, JAMES JOSEPH · 2019 to 2023
$2.1M
NIAID NIH HHS R01 AI139141
6 · The paper itself

Abstract

aimHigh-dose melphalan followed by autologous haematopoietic cell transplantation remains the standard-of-care therapy for multiple myeloma (MM). Gastrointestinal toxicity concomitant with electrolyte derangement is a primary cause of morbidity from transplant. Here, we assessed the dynamics of electrolyte imbalances and its role in hematologic counts and engraftment. Ω Patients and Methods One hundred and eighteen MM patients that received transplant were studied.

resultsEngraftment speed (ES) was calculated as the period between the first rise in the absolute neutrophil count (ANC) and full engraftment defined as the first of three consecutive days with ANC > 500 × 10

conclusionOur results indicate that there is a significant correlation between the magnitude of drop in potassium and phosphorous levels and a steep rise in neutrophil counts around the engraftment period following stem cell transplant. These events indicate a "genesis syndrome" characterized by a rapid, massive transfer of electrolytes into proliferating cells as has been previously described after HCT for certain high-grade lymphomas and leukemias.

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgedFemaleGastrointestinal DiseasesHumansMagnesiumMaleMiddle AgedMultiple MyelomaPhosphorusPotassiumTransplantation, AutologousMagnesiumPhosphorusPotassiumautologous stem cell transplantelectrolyte abnormalitiesmultiple myeloma

Identifiers

PMID32167620
PMCPMC8622572
OpenAlexW3011013373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.