ArticleInternational journal of epidemiology2020
Association between the pregnancy exposome and fetal growth.
Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Update of the human early life exposome (HELIX) cohort: a European population-based exposome cohort-cohort profile.BMJ open · 2026Article
- Gaps in the usage and reporting of multiple imputation for incomplete data: findings from a scoping review of observational studies addressing causal questions.BMC medical research methodology · 2024Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research.Environment international · 2023Article
- Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study.Environmental health perspectives · 2023Article
- Maternal diet quality moderates associations between parabens and birth outcomes.Environmental research · 2022Article
- Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development.Nature communications · 2022Article
- What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory.Chemical research in toxicology · 2022Review
- Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood.Frontiers in genetics · 2022Article
- The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.Environmental toxicology and chemistry · 2022Article
- Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview.Environmental epidemiology (Philadelphia, Pa.) · 2021Review
- Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery.Environmental health : a global access science source · 2021Article
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- Educational note: addressing special cases of bias that frequently occur in perinatal epidemiology.International journal of epidemiology · 2021Article
- The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma.International journal of environmental research and public health · 2021Review
- Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive.Environmental sciences Europe · 2021Review
- Precision medicine in the era of artificial intelligence: implications in chronic disease management.Journal of translational medicine · 2020Review
- Estimating the Combined Effects of Natural and Built Environmental Exposures on Birthweight among Urban Residents in Massachusetts.International journal of environmental research and public health · 2020Article
- The contribution of age-related changes in the gut-brain axis to neurological disorders.Gut microbesReview
Corrections and comments
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Authors and funding
32 authors at 9 institutions in 9 countries.
Funding
Abstract
backgroundSeveral environmental contaminants were shown to possibly influence fetal growth, generally from single exposure family studies, which are prone to publication bias and confounding by co-exposures. The exposome paradigm offers perspectives to avoid selective reporting of findings and to control for confounding by co-exposures. We aimed to characterize associations of fetal growth with the pregnancy chemical and external exposomes.
methodsWithin the Human Early-Life Exposome project, 131 prenatal exposures were assessed using biomarkers and environmental models in 1287 mother-child pairs from six European cohorts. We investigated their associations with fetal growth using a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering each exposure independently. We corrected for exposure measurement error and tested for exposure-exposure and sex-exposure interactions.
resultsThe DSA model identified lead blood level, which was associated with a 97 g birth weight decrease for each doubling in lead concentration. No exposure passed the multiple testing-corrected significance threshold of ExWAS; without multiple testing correction, this model was in favour of negative associations of lead, fine particulate matter concentration and absorbance with birth weight, and of a positive sex-specific association of parabens with birth weight in boys. No two-way interaction between exposure variables was identified.
conclusionsThis first large-scale exposome study of fetal growth simultaneously considered >100 environmental exposures. Compared with single exposure studies, our approach allowed making all tests (usually reported in successive publications) explicit. Lead exposure is still a health concern in Europe and parabens health effects warrant further investigation.
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