ArticleeLife2020
Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 85 citations in OpenAlex.
- Hippocampal long-range GABAergic neurons target hippocampal-projecting cells of the supramammillary area.The Journal of physiology · 2026Article
- Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus-Dentate Gyrus Circuit.CNS neuroscience & therapeutics · 2026Article
- Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing.Molecular psychiatry · 2026Article
- Hippocampo-supramammillary coupling across sleep and wake.Scientific reports · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Perisomatic innervation on the semilunar granule cells and outer molecular layer granule cells of the dentate gyrus of the mouse.Frontiers in neuroanatomy · 2026Article
- Long-lived adult-born hippocampal neurons promote successful cognitive aging.Molecular psychiatry · 2026Article
- Article
- Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity.Neuron · 2025Article
- Impairments of spatial memory retrieval via medial mammillary body dysfunction in Alzheimer's disease model.Translational psychiatry · 2025Article
- Activation of the supramammillary-dentate gyrus circuit enhances alertness and cognitive function in a rat model of ADHD.Translational psychiatry · 2025Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects.Neurobiology of stress · 2025Article
- µ-Opioid Receptor Control of Glutamate/GABA Coreleasing SUM and VTA Projections to the Dentate Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Article
- Article
- Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.Cell reports · 2024Article
- Sex Differences in the Neuroendocrine Stress Response: A View from a CRH-Reporting Mouse Line.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Yadong LiDepartment of Pharmacology, University of North Carolina, Chapel Hill, United States.ORCID https://orcid.org/0000-0002-5977-8760
Hechen Bao *Department of Pharmacology, University of North Carolina, Chapel Hill, United States.
Yanjia Luo *Department of Pharmacology, University of North Carolina, Chapel Hill, United States.ORCID https://orcid.org/0000-0002-1288-438X
Cherasse YoanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Heather Anne SullivanThe McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Luis QuintanillaDepartment of Pharmacology, University of North Carolina, Chapel Hill, United States.
Ian WickershamThe McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Michael LazarusInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0003-3863-4474
Yen-Yu Ian ShihDepartment of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, United States.
Juan SongDepartment of Pharmacology, University of North Carolina, Chapel Hill, United States.ORCID https://orcid.org/0000-0002-7836-343X
University of North Carolina at Chapel Hill · USMcGovern Institute for Brain Research · USUniversity of Tsukuba · JPImaging Center · US
Funding
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5MPreclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7MPreclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOY, SHERYL S · 2013 to 2019
$8.0MCircuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3MMechanisms underlying positive and negative BOLD in the striatumRF1MH117053 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2018 to 2019
$4.0MSex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionR01MH122692 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2020 to 2024
$2.9MChemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7MFunctional dissection of therapeutic deep brain stimulation circuitryR01NS091236 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2015 to 2019
$2.0MNeural circuitry mechanisms regulating adult hippocampal neurogenesisR01MH111773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2016 to 2020
$2.0MRole of TRIM9 in regulating neurogenesis-associated hippocampal functionsR21NS104530 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2018 to 2019
$428kTargeting inhibitory neural network for treatment of Alzheimers diseaseR21AG058160 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2018 to 2019
$425kEmotion-Modulated Psychophysiology of Autism Spectrum DisordersR21MH085254 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENNING, STEPHEN D, DICHTER, GABRIEL S · 2009 to 2010
$416kNIA NIH HHS R21 AG058160NICHD NIH HHS P50 HD103573NICHD NIH HHS U54 HD079124NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH111773NIMH NIH HHS R01 MH122692NIMH NIH HHS R01 MH126518NIMH NIH HHS R21 MH085254NIMH NIH HHS RF1 MH117053NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS091236NINDS NIH HHS R21 NS104530
Abstract
The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG). It remains unknown how the SuM and DG coordinate their activities at the circuit level to regulate spatial memory. Additionally, SuM co-releases GABA and glutamate to the DG, but the relative role of GABA versus glutamate in regulating spatial memory remains unknown. Here we report that SuM-DG Ca
Indexed as
AnimalsCalcium SignalingDentate GyrusFemaleGlutamic AcidHypothalamus, PosteriorMaleMaze LearningMiceMice, Inbred C57BLSpatial MemoryVesicular Inhibitory Amino Acid Transport ProteinsGlutamic AcidVesicular Inhibitory Amino Acid Transport ProteinsViaat protein, mousecalcium imagingfiber photometrymemory encodingmemory retrievalmouseneuroscienceSuM-DG correlationSuM glutamate transmission
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.