ReviewAdvances in nutrition (Bethesda, Md.)2020
Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury.
Review in Advances in nutrition (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06734845 (Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Trends and frontiers in disuse muscle atrophy research.Frontiers in public health · 2025Pooled it
- The role of muscle disuse in muscular and cardiovascular fitness: A systematic review and meta-regression.European journal of sport science · 2024Pooled it
- Effects of Bed Rest on Physical Performance in Athletes: A Systematic and Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Combined action observation and mental imagery versus neuromuscular electrical stimulation as novel therapeutics during short-term knee immobilization.Experimental physiology · 2024Trial
- Nuclear Translocation of PFKFB3 Promotes Disuse-Induced Muscle Atrophy via Scaffolding Nedd4-Mediated JunB Ubiquitination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptomic Profiling Reveals Early Molecular Adaptations to Resistance Exercise During Disuse Muscle Atrophy with Complementary Automated H&E-Based Muscle Morphometry.Life (Basel, Switzerland) · 2026Article
- Development and Preliminary Validation of a Novel Protein Assessment Screening Tool (PAST) for Nutrition Care.Nutrients · 2026Article
- Persistent Human Quadriceps Muscle Volume Deficits Following ACL Reconstruction Are Associated With No Detectable Between-Leg Differences in Vastus Lateralis Muscle Signaling at Rest or Immediately Following Resistance Exercise.Scandinavian journal of medicine & science in sports · 2026Article
- Age- and Treatment-Related Patterns in Fatigue, Coping/Resilience, and Skeletal Muscle Bioenergetics (Biomedicines · 2026Article
- Machine learning-based diagnostic models for prevalent metabolic syndrome among patients with disuse muscle atrophy: a comparative study of seven algorithms.Frontiers in endocrinology · 2026Article
- Decrease in Psoas Muscle Mass and Density Following Liver Transplantation Is Greatest in Patients With the Highest Muscle Quantity and Density Pre-Transplant.Clinical transplantation · 2025Article
- Effectiveness of Open Rigid Internal Fixation of Condylar Fracture Resulting in Temporomandibular Joint Function Recovery.Dentistry journal · 2025Article
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- Advances in Nutritional and Therapeutic Strategies for Type 2 Intestinal Failure: A Narrative Review.Nutrition reviews · 2025Review
- Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.Antioxidants (Basel, Switzerland) · 2025Article
- Mature and Juvenile Neuromuscular Plasticity in Response to Unloading.Developmental neurobiology · 2025Article
- Physiological and morphological impact of physical activity and nutritional interventions to offset disuse-induced skeletal muscle atrophy.European journal of translational myology · 2025Article
- Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.Journal of functional morphology and kinesiology · 2025Article
- Nutritional Interventions to Attenuate Quadriceps Muscle Deficits following Anterior Cruciate Ligament Injury and Reconstruction.Sports medicine (Auckland, N.Z.) · 2025Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle atrophy and weakness occur as a consequence of disuse after musculoskeletal injury (MSI). The slow recovery and persistence of these deficits even after physical rehabilitation efforts indicate that interventions designed to attenuate muscle atrophy and protect muscle function are necessary to accelerate and optimize recovery from MSI. Evidence suggests that manipulating protein intake via dietary protein or free amino acid-based supplementation diminishes muscle atrophy and/or preserves muscle function in experimental models of disuse (i.e., immobilization and bed rest in healthy populations). However, this concept has rarely been considered in the context of disuse following MSI, which often occurs with some muscle activation during postinjury physical rehabilitation. Given that exercise sensitizes skeletal muscle to the anabolic effect of protein ingestion, early rehabilitation may act synergistically with dietary protein to protect muscle mass and function during postinjury disuse conditions. This narrative review explores mechanisms of skeletal muscle disuse atrophy and recent advances delineating the role of protein intake as a potential countermeasure. The possible synergistic effect of protein-based interventions and postinjury rehabilitation in attenuating muscle atrophy and weakness following MSI is also considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.